Role of immune response cytokine regulation disorders in the development of endothelial dysfunction in diabetes mellitus type 2
Цифровий Репозиторій - Інтелектуальні Фонди Буковинського державного медичного університету
Переглянути архів Інформація| Поле | Співвідношення | |
| Title |
Role of immune response cytokine regulation disorders in the development of endothelial dysfunction in diabetes mellitus type 2
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| Creator |
Pashkovska, Nataliya
Olenovych, Olha |
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| Subject |
diabetes mellitus
pro-inflammatory cytokines endothelial dysfunction functional state of endothelium цукровий діабет прозапальні цитокіни ендотеліальна дисфункція функціональний стан ендотелію сахарный диабет провоспалительные цитокины эндотелиальная дисфункция функциональное состояние эндотелия |
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| Description |
With the aim to define the role of disorders of the immune response cytokine regulation in the development of endothelial dysfunction in patients with DM type 2, the degree of insulin resistance, functional state of the endothelium, blood serum level of pro-inflammatory cytokines were investigated. The processes of vascular endothelium desquamation were found to be enhanced in diabetes mellitus type 2, followed by a reliable increase of endotheliocytemia, reduction of endotheliumdependent vasodilation, elevation of blood serum level of endothelin-1 and decrease of stable nitrogen monoxide metabolites in the blood. The degree of endothelial dysfunction manifestation in diabetes mellitus type 2 depends on the indices of insulin resistance (waist circumference, insulinemia, HOMA-IR index) and is connected with the enhanced expression of pro-inflammatory cytokines (tumor necrosis factor-α, interleukin-1-β, interleukin-6, interleukin-8).
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| Publisher |
Pharmacologyonline
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| Date |
2012-06-11T12:54:01Z
2012-06-11T12:54:01Z 2011 |
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| Type |
Article
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| Identifier |
http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/1733
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