Pharmacological correction of endothelial dysfunction in patients with HIV-infection/AIDS
Цифровий Репозиторій - Інтелектуальні Фонди Буковинського державного медичного університету
Переглянути архів Інформація| Поле | Співвідношення | |
| Title |
Pharmacological correction of endothelial dysfunction in patients with HIV-infection/AIDS
|
|
| Creator |
Moskaliuk, V.D.
Sorokhan, V.D. Melenko, S.R. Vozna, K.I. Balaniuk, I.V. |
|
| Subject |
endothelial dysfunction
treatment HIV/AIDS |
|
| Description |
On the basis of inspection 127 patients with HIV-infection/AIDS it has been established that in case of this pathology the concentration of thrombomodulin, Е-selectin and von Willebrand’s factor substantially grows, which is indicative of a HIV-induced affection of the vascular wall. As immunodeficiency progresses, the concentration of all the mentioned indices grows significantly. 3-month symptomatic therapy does not influence on the state of the endothelium. The use of the dipiridamol, aggregant, and also a 3-month antiretroviral treatment of the first row provide only a partial decline of the thrombomodulin, Е-selectin and von Willebrand’s factor levels. However, the inclusion to the antiretroviral therapy (ART) of dipiridamol maximally optimizes the endothelial state of the endothelium: the level of thrombomodulin and von Willebrand’s factor at the IInd clinical stage of HIV-infection normalizes and at the IIId-IVth stages – significantly lowers, although it does not reach the values of healthy persons. The same ponderable difference is established in relation to the content of Е-selectin. |
|
| Date |
2013-01-02T20:36:23Z
2013-01-02T20:36:23Z 2012 |
|
| Type |
Article
|
|
| Identifier |
http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/4887
|
|
| Language |
en
|
|
| Relation |
Т. 16, № 4 (64);с. 116-120
|
|
| Format |
application/pdf
|
|
| Publisher |
Буковинський медичний вісник
|
|