Combined effects of ACE (I/D) and eNOS (894T>G) genes polymorphism in patients with arterial hypertension in the realization of molecular mechanisms of left ventricular hypertrophy
Цифровий Репозиторій - Інтелектуальні Фонди Буковинського державного медичного університету
Переглянути архів Інформація| Поле | Співвідношення | |
| Title |
Combined effects of ACE (I/D) and eNOS (894T>G) genes polymorphism in patients with arterial hypertension in the realization of molecular mechanisms of left ventricular hypertrophy
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| Creator |
Sydorchuk, L.P.
Gaborets, I.Y. Sydorchuk, A.R. Ursulyak, Yu.V. Sokolenko, A.A. Ivashchuk, S.I. Biryuk, I.G. Kostenko, V.V. |
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| Subject |
genes ACE (I/D) and eNOS (893T>G)
arterial hypertension left ventricular hypertrophy |
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| Description |
Aim: To determine the frequency of alleles and genotypes of insertion-deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) (dbSNP id: rs4646994) and a missense mutation (894T
Materials and methods: 120 patients with EAH I-III stages (48.3% - women, 51.7% - men, average age 52.9±9.24 years) and 40 practically healthy persons were observed. Alleles of polymorphic locus was studied by polymerase chain reaction (PCR). Structural and functional changes of the myocardium and LVH models - by echocardiography, ECG. The results analyzed according to the European guidelines ESC / ESH (2009). Results and discussions: One-third of patients with EAH (35.8%) have a mutation in the coding regions of the ACE gene (I/D, intron 16, 17q23, dbSNP id: rs4646994) or eNOS (894T0.05) and “good” patterns of left ventricular geometric structure in 2.53 times (OR=7.87, p=0.04). Conclusions: ID/TG and DD/TG combination of genotypes of the ACE gene (I/D) and eNOS (893T>G) is an additional independent predictor of target-organ damage, in particular the appearance of left ventricular hypertrophy, and the severity of EAH. |
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| Date |
2013-06-01T07:13:23Z
2013-06-01T07:13:23Z 2013 |
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| Type |
Other
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| Identifier |
http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/6704
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| Language |
en
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| Format |
application/pdf
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| Publisher |
The New Armenian Medical Journal
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