Giant-cell epulis: immunohistochemical analysis of MGMT, p53, OPN and ММР-1
Electronic Archive of Sumy State University
Переглянути архів Інформація| Поле | Співвідношення | |
| Title |
Giant-cell epulis: immunohistochemical analysis of MGMT, p53, OPN and ММР-1
Epulis gigantocelularis: imunohistochemická analýza MGMT, p53, OPN a MMP-1 |
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| Creator |
Кузенко, Євген Вікторович
Кузенко, Евгений Викторович Kuzenko, Yevhen Viktorovich Романюк, Анатолій Миколайович Романюк, Анатолий Николаевич Romaniuk, Anatolii Mykolaiovych |
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| Subject |
immunohistochemistry
p53 oral giant-cell epulis osteopontin MGMT ММР-1 |
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| Description |
Object: The object of this study was to analyze the expression of MGMT, p53, OPN and ММР-1 in giant-cell epulis. Methods: 10 giant-cell epulis were evaluated for expression of MGMT, p53, OPN and ММР-1 by immunohistochemistry. Results: Strong giant-cell positivity for MGMT was observed in 96.9±0.5% (P < 0.05). Strong mesenchymal immunoreactivity for MMP-1 was figured in giant-cell, 75.9±1.33% and in the stroma 54.12±1.36% (P<0.05). Immunoreactivity for OPN was fixed in the giant-cell of epulis 15.77±1.8%., positivity for p53 was found in 5.67±0.32% of giant-cell contrast and in the stroma 0%. Conclusion: MGMT, p53 and OPN may play important roles in the biology of giant-cell epulis. Furthermore, the ММР-1 of these proteases at higher levels in giant-cell epulis may help to explain invasion in bone matrix. |
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| Publisher |
Trios
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| Date |
2013-08-27T08:35:52Z
2013-08-27T08:35:52Z 2013-08-14 |
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| Type |
Article
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| Identifier |
Kuzenko, Y. Giant-cell epulis: immunohistochemical analysis of MGMT, p53, OPN and ММР-1 [Text] / Y.Kuzenko., A.Romaniuk // Osteologický bulletin. - 2013. - Vol.18(3). - P. 87–9.
http://essuir.sumdu.edu.ua/handle/123456789/31872 |
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| Language |
en
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