Micellar Structures of PAAm-b-PEO-b-PAAm Triblock Copolymers: Formation, Morphology, and Application as Drug Carries
Electronic Archive of Sumy State University
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| Title |
Micellar Structures of PAAm-b-PEO-b-PAAm Triblock Copolymers: Formation, Morphology, and Application as Drug Carries
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| Creator |
Zheltonozhskaya, T.V.
Partsevskaya, S.V. Klymchuk, D.O |
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| Subject |
Triblock Copolymer
Intramolecular Polycomplex Micellization Drug Encapsulation |
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| Description |
The micellization of asymmetric PAAm-b-PEO-b-PAAm triblock copolymers (TBCs) with increasing length of chemically complementary polyacrylamide and poly(ethylene oxide) blocks was studied using static light scattering, photography, UV-Vis spectroscopy and TEM. The formation of “hairy-type” and “flower-like” micelles was established in dilute aqueous and aqueous/ethanol solutions. The “hairy” micelles contained a “core” comprised cooperatively interacting PEO and PAAm segments and “corona” formed by unbound units of longer PAAm blocks. Appearance of the “flower-like” micelles was conditioned by insolubility of PAAm blocks. Stability of the “flower-like” micelles was higher than that of the "hairy-type" ones. Significant encapsulation of a model drug prednisolon by TBC micelles was established. |
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| Publisher |
Sumy State University
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| Date |
2014-05-22T07:36:47Z
2014-05-22T07:36:47Z 2012 |
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| Type |
Article
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| Identifier |
Zheltonozhskaya, T.V.
Micellar Structures of PAAm-b-PEO-b-PAAm Triblock Copolymers: Formation, Morphology, and Application as Drug Carries [Текст] / T.V. Zheltonozhskaya, S.V. Partsevskaya, D.O. Klymchuk
// Nanomaterials: Applications & Properties (NAP-2012) : 2-nd International conference, Alushta, the Crimea, September 17-22, 2012 / Edited by: A. Pogrebnjak. - Sumy : Sumy State University, 2012. - V.1, No1. - 01PCN07
http://essuir.sumdu.edu.ua/handle/123456789/34795 |
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| Language |
en
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