Anionic Micelle-Forming Triblock Copolymers as Nanocontainers for Doxorubicin
Electronic Archive of Sumy State University
Переглянути архів Інформація| Поле | Співвідношення | |
| Title |
Anionic Micelle-Forming Triblock Copolymers as Nanocontainers for Doxorubicin
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| Creator |
Kunitskaya, L.R.
Stoika, R.S. Shlyakhtina, Ye.A. Zheltonozhskaya, T.B. Permyakova, N.M. Boiko, N.M |
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| Subject |
Amphiphilic Block Copolymers
Drug Micellization Poly(Ethylene Oxide) Polyacrylamide |
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| Description |
The anionic derivative of asymmetric triblock copolymer containing biocompatible chemically complementary polyacrylamide and poly(ethylene oxide) (PAAm-b-PEO-b-PAAm) was obtained. The micellization of the initial (TBC) and modified (TBC-COOH) copolymer samples in aqueous solution were investigated. Practically the same values of the critical micellization concentration and the Gibbs free micellization energy for both TBCs were found. The anticancer effects of the doxorubicin (DOX)-loaded micelles of the initial and modified triblock copolymers were studied on the tumor cells of human T-leukemia of Jurkat line, transformed leukemia of L929 line and mouse lymphatic leukemia of L1210 line. The fact of high efficacy of DOX/TBC and DOX/TBC-COOH compositions in compare with pure DOX was determined and discussed. |
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| Publisher |
Sumy State University
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| Date |
2014-05-26T08:32:15Z
2014-05-26T08:32:15Z 2012 |
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| Type |
Article
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| Identifier |
Anionic Micelle-Forming Triblock Copolymers as Nanocontainers for Doxorubicin / L. R. Kunitskaya, R. S. Stoika, Y. A. Shlyakhtina et al.
// Nanomaterials: Applications & Properties (NAP-2012) : 2-nd International conference, Alushta, the Crimea, September 17-22, 2012 / Edited by: A. Pogrebnjak. - Sumy : Sumy State University, 2012. - V. 1, No2. - 02NNBM10
http://essuir.sumdu.edu.ua/handle/123456789/34970 |
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| Language |
en
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