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Preparation and Medico-Biological Tests Nanocolloids Radiopharmaceuticals on the Based of Modified DTPA Labeled Technetium-99m

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Title Preparation and Medico-Biological Tests Nanocolloids Radiopharmaceuticals on the Based of Modified DTPA Labeled Technetium-99m
 
Creator Scuridin, V.S.
Stasyuk, E.S.
Nesterov, E.A.
Rogov, A.S.
Sadkin, V.L.
Varlamova, N.V.
 
Subject Technetium-99m
Modified molecule DTPA
Molybdenum
Nanocolloid labeled technetium- 99m
 
Description Technetium-99m recovery process in the presence of stannous Sn (II) with the aim to determine it is
necessary and sufficient quantity, that would provide a complete "recovery" of 99mTc in the reaction mixture
has been investigated. The studies were identified conditions for receiving radioactive nanopreparations
based on a modified molecule DTPA. The authors has been shown that the direct interaction of
99mTc eluate solution with a solution of a mixture of SnCl2 DTPAmod and radiochemical impurity content
unreduced 99mTc (VII) in the preparation labeled with nanocolloids is 2,7% and the yield nanocolloids
with the size of 100 nm is about 80%. The medical-biological testing of the agents 99mTc (IV) - DTPAmod
on test animals for the determination of the functional suitability for the scintigraphic imaging of lymph
nodes has been carried out.
 
Publisher Sumy State University
 
Date 2014-05-29T09:48:38Z
2014-05-29T09:48:38Z
2013
 
Type Article
 
Identifier Preparation and Medico-Biological Tests Nanocolloids Radiopharmaceuticals on the Based of Modified DTPA Labeled Technetium-99m [Текст] / V.S. Scuridin, E.S. Stasyuk, E.A. Nesterov et al. // Nanomaterials: Applications & Properties (NAP-2013) : 2-nd International conference, Alushta, the Crimea, September 17-22, 2012 / Edited by: A. Pogrebnjak. - Sumy : Sumy State University, 2013. - V.2, No4. - 04NABM02
http://essuir.sumdu.edu.ua/handle/123456789/35405
 
Language en