Pharmacogenetic aspects of basic anti- inflammatory therapy of bronchial asthma in school-aged children under the deletion polymorphism of genes Gstt1 and Gstm1
Цифровий Репозиторій - Інтелектуальні Фонди Буковинського державного медичного університету
Переглянути архів Інформація| Поле | Співвідношення | |
| Title |
Pharmacogenetic aspects of basic anti- inflammatory therapy of bronchial asthma in school-aged children under the deletion polymorphism of genes Gstt1 and Gstm1
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| Creator |
Koloskova, Olena Kostiantunivna
Bilous, Tetiana Muchailivna Mikaliuk, Ludmila Viktorivna Ortemenka, Evgenia Pavlivna |
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| Subject |
bronchial asthma
children glutathione-S-transferase |
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| Description |
Based on a comprehensive survey of 150 school-age children who suffer from bronchial asthma, there has been found that homozygosity for both alleles of the gene of glutathione transferase (GSTT1+ M1+) was associated with more frequent use both inhaled corticosteroids at 3 Step 3 of basic therapy and leukotriene modifiers as well as better asthma control level according to the ACT-test. Under the presence of such genotypes as GSTT1+ M1-, GSTT1-M1+ or GSTT1-M1-, the basic treatment was more likely within 2-nd and 4-th Steps by GINA recommendations, but the level of asthma control was worse in these children. |
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| Date |
2015-02-26T07:41:28Z
2015-02-26T07:41:28Z 2014 |
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| Type |
Article
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| Identifier |
http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/8256
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| Language |
en
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| Relation |
THE PHARMA INNOVATION - JOURNAL ;Vol. 2 No. 12.
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| Format |
application/pdf
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