Humoral markers of endothelial dysfunction and systemic inflammatory response in patients with acute myocardial infarction depending on genes polymorphism of ACE (I/D) and eNOS (894G>T)
Цифровий Репозиторій - Інтелектуальні Фонди Буковинського державного медичного університету
Переглянути архів Інформація| Поле | Співвідношення | |
| Title |
Humoral markers of endothelial dysfunction and systemic inflammatory response in patients with acute myocardial infarction depending on genes polymorphism of ACE (I/D) and eNOS (894G>T)
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| Creator |
Sydorchuk, L.P.
Ursuliak, U.V. Sydorchuk, A. Makoviychuk, I. Trutiak, V. Biryuk, I. |
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| Subject |
ACE (I/D)
eNOS (894G>T) genes myocardial infarction endothelium treatment |
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| Description |
The dynamics of endothelial dysfunction (ED) humoral factors: a soluble form of vascular cell adhesion molecule 1 (sVCAM-1), total NO metabolites and systemic inflammatory response - C-reactive protein (CRP) in patients with acute myocardial infarction (MI) under the influence of treatment and depending on genes polymorphism – angiotensin converting enzyme (ACE, I/D) and endothelial nitric oxide synthase (eNOS, T894G) were evaluated. The presence of DD-genotype of ACE gene is associated with a significantly greater decrease of sVCAM-1 and CRP levels under the influence of treatment (better with thrombolytic therapy (TLT), p<0.05); in T- allele carriers of eNOS gene the level sVCAM-1 under TLT decreased by 30.7-31.2%. Content of NO metabolites decreased more in D-allele carriers of ACE gene as well as after combined treatment with TLT (39.1% and 35.2%) and did not depend on the allele state of eNOS gene. |
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| Date |
2015-05-20T05:36:01Z
2015-05-20T05:36:01Z 2014 |
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| Type |
Other
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| Identifier |
http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/8879
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| Language |
en
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| Format |
application/pdf
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| Publisher |
The Pharma Innovation-Journal
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