Chimerism and multiple numerical chromosome imbalances in a spontaneously aborted fetus
Vernadsky National Library of Ukraine
Переглянути архів Інформація| Поле | Співвідношення | |
| Title |
Chimerism and multiple numerical chromosome imbalances in a spontaneously aborted fetus
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| Creator |
Vorsanova, S.G.
Iourov, I.Y. Demidova, I.A. Kirillova, E.A. Soloviev, I.V. Yurov, Y.B. |
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| Subject |
Оригинальные работы
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| Description |
We report on a case of chimerism and multiple abnormalities of chromosomes 21, X and Y in spontaneous abortion specimen. To the best our knowledge the present case is the first documented chimera in a spontaneously aborted fetus. The application of interphase fluorescence in situ hybridization (FISH) using chromosome enumeration and site-specific DNA probes showed trisomy X in 92 nuclei (23 %), tetrasomy X in 100 nuclei (25 %), pentasomy of chromosome X in 40 nuclei (10 %), XXY in 36 nuclei (9 %), XXXXXXYY in 12 nuclei (3 %), XXXXXYYYYY in 8 nuclei (2 %), trisomy 21 and female chromosome complement in 40 nuclei (10 %), normal female chromosome complement in 72 nuclei (18 %) out of 400 nuclei scored. Our experience indicates that the frequency of chimerism coupled with multiple chromosome abnormalities should be no less than 1 : 400 among spontaneous abortions. The difficulties of chimerism identification in fetal tissues are discussed.
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| Date |
2015-05-24T16:08:30Z
2015-05-24T16:08:30Z 2006 |
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| Type |
Article
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| Identifier |
Chimerism and multiple numerical chromosome imbalances in a spontaneously aborted fetus / S.G. Vorsanova, I.Y. Iourov, I.A. Demidova, E.A. Kirillova, I.V. Soloviev, Y.B. Yurov // Цитология и генетика. — 2006. — Т. 40, № 5. — С. 28-30. — Бібліогр.: 7 назв. — англ.
0564-3783 http://dspace.nbuv.gov.ua/handle/123456789/82073 |
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| Language |
en
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| Relation |
Цитология и генетика
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| Publisher |
Інститут клітинної біології та генетичної інженерії НАН України
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