Вплив рабепразолу на симптоми бронхіальної астми при поєднанні її з гастроезофагеальною рефлюксною хворобою
Electronic Archive of Sumy State University
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| Title |
Вплив рабепразолу на симптоми бронхіальної астми при поєднанні її з гастроезофагеальною рефлюксною хворобою
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Винниченко, Людмила Боголюбівна
Винниченко, О.І. Винниченко, Людмила Боголюбовна Vynnychenko, Liudmyla Boholiubivna |
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| Description |
Досліджували поширеність патологічного гастроезофагеального рефлексу (ГЕР) у хворих на бронхіальну астму (БА) та вплив рабепразолу на симптоми БА й основні показники функції зовнішнього дихання.
To investigate the prevalence of gastroesophageal reflux (GER) among patients with asthma and to determine the effect of rabeprazole on the outcome of asthma in patients with GER. The patients who were found to have GER in ambulatory esophageal pH monitoring were divided for 2 groups. First group received rabeprasole, 40 mg ро, for 8 weeks, second group served as a control group. After 2-week washout period, the patients were crossed over to the treatment and first group was a control group and patients of second one received rabeprasole, 40 mg ро, for next 8 weeks. Spirometry was performed at baseline and immediately after both treatment periods. Peak expiratory values, use of sympathomimetics, and pulmonary and gastric symptoms were recorded daily in a diary. Results: Pathologic GER was found in 53% of the asthmatic patients. One third of these patients had no typical reflux symptoms. Daytime pulmonary symptoms did not improve significantly, but a reduction in nighttime asthma symptoms was found during rabeprazole treatment. In the patients with intrinsic asthma, there was an improvement in FEV1 values. Based on symptoms scores, 35% of the patients were regarded as responders to 8-week rabeprazole treatment. The reflux (time [percent]of pH <4) was found to be more severe in the responders. |
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Видавництво СумДУ
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| Date |
2010-12-20T08:14:08Z
2010-12-20T08:14:08Z 2006 |
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| Type |
Article
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| Identifier |
Винниченко, Л.Б. Вплив рабепразолу на симптоми бронхіальної астми при поєднанні її з гастроезофагеальною рефлюксною хворобою [Текст] / Л.Б. Винниченко, О.І. Винниченко // Вісник Сумського державного університету. Серія Медицина. — 2006. — №2(86). — С. 108-115.
http://essuir.sumdu.edu.ua/handle/123456789/666 |
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| Language |
uk
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