Polyfunctional pyrazoles. 9. Synthesis of 1-alkyl(aryl)-3-[4-(hydroxymethyl)-1h-pyrazol-3-yl]ureas
Цифровий Репозиторій - Інтелектуальні Фонди Буковинського державного медичного університету
Переглянути архів Інформація| Поле | Співвідношення | |
| Title |
Polyfunctional pyrazoles. 9. Synthesis of 1-alkyl(aryl)-3-[4-(hydroxymethyl)-1h-pyrazol-3-yl]ureas
|
|
| Creator |
Bratenko, M.K.
Barus, M.M. Rotar, D.V. Vovk, M.V. |
|
| Subject |
4-hydroxymethylpyrazole-3-carbonyl azides
(pyrazol-3-yl)ureas pyrazolo[3,4-d][1,3]ox-azines intramolecular cyclization |
|
| Description |
We have developed an effective method for the preparation of 1-alkyl(aryl)-3-[4-(hydroxymethyl)-1Н-pyrazol-3-yl]ureas based on the interaction of 4-hydroxymethylpyrazole-3-carbonyl azides with primary aliphatic and aromatic amines under the conditions of Curtius reaction. In the absence of amines in the reaction mixture, in situ generated 4-hydroxymethyl-3-isocyanatopyrazoles underwent intramolecular cyclization to pyrazolo[3,4-d][1,3]oxazin-6(4Н)-ones. The latter showed a tendency to form 1-alkyl(aryl)-3-[4-(hydroxymethyl)-1Н-pyrazol-3-yl]ureas in the presence of amines
|
|
| Date |
2015-10-15T10:06:56Z
2015-10-15T10:06:56Z 2014 |
|
| Identifier |
БДМУ
http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/9533 |
|
| Format |
application/pdf
|
|
| Publisher |
Chemistry of heterocyclic compounds. – 2014. – Vol.50. – No.9 (december)
|
|