POLYFUNCTIONAL PYRAZOLES. 9*. SYNTHESIS OF 1-ALKYL(ARYL)-3-[4-(HYDROXYMETHYL)-1Н-PYRAZOL-3-YL]UREAS
Цифровий Репозиторій - Інтелектуальні Фонди Буковинського державного медичного університету
Переглянути архів Інформація| Поле | Співвідношення | |
| Title |
POLYFUNCTIONAL PYRAZOLES. 9*. SYNTHESIS OF 1-ALKYL(ARYL)-3-[4-(HYDROXYMETHYL)-1Н-PYRAZOL-3-YL]UREAS
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| Creator |
Bratenko, M. K.
Barus, M. M. Rotar, D. V. Vovk, M. V. |
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| Subject |
4-hydroxymethylpyrazole-3-carbonyl azides
(pyrazol-3-yl)ureas, pyrazolo[3,4-d][1,3]ox-azines intramolecular cyclization |
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| Description |
We have developed an effective method for the preparation of 1-alkyl(aryl)-3-[4-(hydroxymethyl)-1Н-pyrazol-3-yl]ureas based on the interaction of 4-hydroxymethylpyrazole-3-carbonyl azides with primary aliphatic and aromatic amines under the conditions of Curtius reaction. In the absence of amines in the reaction mixture, in situ generated 4-hydroxymethyl-3-isocyanatopyrazoles underwent intramolecular cyclization to pyrazolo[3,4-d][1,3]oxazin-6(4Н)-ones. The latter showed a tendency to form 1-alkyl(aryl)-3-[4-(hydroxymethyl)-1Н-pyrazol-3-yl]ureas in the presence of amines.
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| Date |
2015-11-02T12:14:01Z
2015-11-02T12:14:01Z 2014 |
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| Type |
Article
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| Identifier |
http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/9748
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| Language |
en
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| Relation |
Vol. 50, No. 9;P.1252-1258
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| Format |
application/pdf
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| Publisher |
Chemistry of Heterocyclic Compounds
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