Chitosan–hydroxyapatite composite biomaterials made by a one step co-precipitation method: preparation, characterization and in vivo tests
Electronic Archive of Sumy State University
Переглянути архів Інформація| Поле | Співвідношення | |
| Title |
Chitosan–hydroxyapatite composite biomaterials made by a one step co-precipitation method: preparation, characterization and in vivo tests
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| Creator |
Danylchenko, Serhii Mykolaiovych
Kalinkevich, Oksana Vladimirovna Pogorelov, Maksim Vladimirovich Данильченко, Сергій Миколайович Данильченко, Сергей Николаевич |
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| Subject |
biodegradation
chitosan hydroxyapatite osteogenesis scaffolds |
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| Description |
A series of biocompatible chitosan/hydroxyapatite composites has been synthesized in an aqueous medium from chitosan solution and soluble precursor salts by a one-step coprecipitation method. The composite materials were produced in dense and porous variants. XRD and IR studies have shown that the apatite crystals in the composites have structural characteristics similar to those of crystals in biogenic apatite. A study of in vivo behaviour of the materials was carried out. Cylindrical rods made of the chitosan/ hydroxyapatite composite material were implanted into the tibial bones of rats. After 5, 10, 15 and 24 days of implantation, histological and histo-morphometric analyses of decalcified specimens were undertaken to evaluate their biocompatibility and the possibility to apply them in bone tissue engineering. The calcified specimens were examined by scanning electron microscopy combined with X-ray microanalysis to compare the elemental composition and morphological characteristics of the implant and the bone during integration. Porous specimens were osteoconducting and were replaced in vivo by newly formed bone tissue. |
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| Publisher |
Collegium Basilea & AMSI
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| Date |
2011-01-25T07:23:05Z
2011-01-25T07:23:05Z 2009 |
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| Type |
Article
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| Identifier |
Journal of Biological Physics and Chemistry 9 (2009) 119–126
http://essuir.sumdu.edu.ua/handle/123456789/2703 |
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| Language |
en
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