FEATURES OF HYPOGLYCEMIC EFFECT OF DRY EXTRACT FROM THE DANDELION ROOTS AND RHIZOMES DEPENDING ON THE DOSE
Наукові журнали Тернопільського державного медичного університету імені І.Я.Горбачевського
Переглянути архів Інформація| Поле | Співвідношення | |
| Title |
FEATURES OF HYPOGLYCEMIC EFFECT OF DRY EXTRACT FROM THE DANDELION ROOTS AND RHIZOMES DEPENDING ON THE DOSE
|
|
| Creator |
Ezhned, M. A.; Ternopil State Medical University, Ternopil
Hroshovyi, T. A. Horoshko, О. М. |
|
| Description |
FEATURES OF HYPOGLYCEMIC EFFECT OF DRY EXTRACT FROM THE DANDELION ROOTS AND RHIZOMES DEPENDING ON THE DOSEM. A. Ezhned1, T. A. Hroshovyi2, О. М. Horoshko1Bukovynian State Medical University1, ChernivtsiHorbachevsky Ternopil State Medical University 2Introduction. Diabetes mellitus (DM) and its complications remains one of the most serious health, social and economic problems of modern health care. In the structure of endocrine diseases diabetes mellitus takes about 60-70%.The mortality in risk group increases by 25%. Today in the world about 382 million people suffer from diabetes, and by 2035, according to the International Diabetes Federation, this figure will increase by 55%, mainly due to patients with diabetes type 2. Among the drugs of official medicine are one-component: blueberry shoots, fruit beans leaves and multi compound preparations: "Arphasetin", "Phytoglunor."One of the most promising medicinal plants with hypoglycemic action is dandelion.The aim of this work was to study dry extract of the roots and rhizomes dandelion depending on the dose in terms of glucose load using intraperitoneal glucose tolerance test (VTTH).Materials and methods. For research was used dry extract of dandelion roots and rhizomes in 60% extractant with intragastric administration in 1% starch paste. For comparing was chosen collection "Arphasetin", in which includes a set of biologically active substances, which shows hypoglycemic effect in diabetes mellitus type II.Results and discussion. Comparing with the original data, the intraperitoneal administration of glucose at a dose of 3 g / kg led to development of acute hyperglycemia, which manifested in significant increase of glucose level in all groups of animals. Thus, in rats of control group the blood glucose was higher at 2.02 times compared with baseline.Oral administration of dry extract of the roots and rhizomes of dandelion to diabetic rats significantly reduced blood glucose as compared with control group.According to our results was found that the single dose of the extract at a dose of 0.8 mg / kg of glucose increased only in 1.34 times, at a dose of 0.1 mg / kg - in 1.23 times, at a dose of 0.12 mg / kg - in 1.29 times, with increasing the dose of the extract to 0.22 mg / kg glucose levels are increased, which manifested itself in increasing the difference between the experimental data and outpAccording to our experiment should be noted that the smallest difference between the level of glucose in animals that received glucose load and baseline, and a model of the pathology was observed in the group of animals injected with dandelion extract at a dose of 0.1 mg / kg, as evidenced by indicators of hypoglycemic action.Thus, in animals injected with extract at a dose of 0.08 mg / kg the hypoglycemic effect was 39.4%, respectively, in the group of animals that received the extract at a dose of 0.1 mg / kg - 40.06%.Further, with increasing doses of dandelion dry extract hypoglycemic effect is reduced from 38.29% (0.12 mg / kg) to 30.08% (0.22 mg / kg) respectively. In the group of animals who received the comparator (collection "Arphasetin") hypoglycemic effect was 16%.So the most hypoglycemic effect was after using the dandelion extract in a dose of 0.1 mg / kg, which was experimentally proved as compared with the original data (in 1.23 times) and control (in 1.66 times), and as compared to "Arphasetin" the hypoglycemic effect was higher at 24.06%, or 2.5 times.Conclusions:1. In experiments was found that the most hypoglycemic effect showed the dandelion dry extract at a dose of 0.1 mg / kg.2. Increasing of concentrations of dandelion dry extract leads to a decrease of hypoglycemic action.References:Dovidnik osnovnih pokaznikiv diyalnosti endokrinologichnoyi sluzhbi Ukrayini za 2014 rik . — K., 2015. — 38 s.Ezhned M. A. Oman visokiy - dzherelo tsinnih biologichno aktivnih rechovin ta perspektivna sirovina dlya stvorennya likarskih preparativ / M.A. Ezhned, T.A. Groshoviy // FItoterapiya. Chasopis .- 2015. - № 2. - S.15-18.Kvasova T. M. Issiedovanie gipoglikemicheskih svoystv i himicheskogo sostava novogo vodorastvorimogo ekstrakta sbora arfazetin suhogo: dissertatsiya ... kandidata biologicheskih nauk : 14.03.06 / Kvasova Tatyana Mihaylovna. - Tver, 2012. - 146 s.Kit S.M., Turchin I.S. Lekarstvennyie rasteniya v endokrinologii.- K.:Zdorovya, 1986.- 80 s.- S15-17.Kihtyak O.P. Osoblivosti pokaznikiv vuglevodnogo obminu pri tsukrovomu diabeti za umov koriguyuchoyi fItoterapiyi (ekperimentalno-klinichne doslidzhennya): avtoref. dis.kand. med. nauk: 14.03.04 / Kihtyak Olesya Pavlivna. - Ternopil, 2002. - 19 s.Medvid I. I. Tsukroznizhuvalna diya spirtovoyi nastoyki z listya shovkovitsi chornoyi / I. I. Medvid, L. S. Fira // Zaporozhskiy meditsinskiy zhurnal. - 2011. - T. 13, № 4. - S. 116-118.Mihaylenko O. Yu. Suchasna terapiya tsukrovogo diabetu 2-go tipu z vikoristannyam predstavnika grupi preparativ sulfonilsechovini – gliklazidu spovilnenogo vivilnennya virobnitstva PAT «Farmak» / O. Yu. Mihaylenko // Mezhdunarodnyiy endokrinologicheskiy zhurnal. – T. 2, № 66. - 2015 - S.52-56Novikov V. P. FItozasobi v likuvanni tsukrovogo diabetu: (oglyad literaturi) / V. P. Novikov, R. T. Konechna, N. E. Stadnitska // Fitoterapiya. Chasopis. - 2007. - № 3. - S. 9-15Menshikov V. V. Laboratornyie metodyi issledovaniya v klinike: Spravochnik / L. N. Delektorskaya, R. P. Zolotnitskaya [i dr.]. M. : Meditsina, 1987. – S. 122, 179–180.Ryibolovlev Yu. R. Dozirovanie veschestv dlya mlekopitayuschih po konstantam biologicheskoy aktivnosti / Yu. R. Ryibolovlev, R. S. Ryibolovlev // Dokladyi AN SSSR. – 1979. – T. 247, № 6.– S. 1513–1516.Tsimbalista Yu. A. Porivnyalne farmakognostichne doslidzhennya predstavnikiv rodu Helianthus L.: sonyashnika odnorichnogo ta sonyashnika bulbistogo: avtoref. dis. kand. farmatsevt. nauk : 15.00.02 / Tsimbalista Yuliya Andriyivna. - Zaporizhzhya, 2015. - 23 s.Yakovleva, L.V. Vivchennya farmakologichnih vlastivostey novogo tsukroznizhuvalnogo roslinnogo zboru / L.V. Yakovleva, O.Yu. Koshova // Klinichna farmatsiya. 2005. T. 9, № 2.. Yakovleva L. V. Vpliv roslinnogo zboru na lipidniy obmin ta pokazniki perekisnogo okisnennya lipidiv u schuriv v umovah eksperimentalnoyi tolerantnosti do glyukozi / L. V. Yakovleva, O. Yu. Koshova // Klinich. farmatsiya. - 2004. - 8, № 4. - S. 38-414. Alberti K.G. Diabetes: alooktothefuture / K. G. Alberti, P. Z. Zimmet // LancetDiabetesEndocrinol. - 2014. - Vol. 2, № 1. - P. 1-2.http://mozdocs.kiev.ua/likiview.php?id=30033
|
|
| Publisher |
Тернопільський державний медичний університет ім. І.Я. Горбачевського
|
|
| Contributor |
—
|
|
| Date |
2016-04-07
|
|
| Type |
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion — |
|
| Format |
application/pdf
|
|
| Identifier |
http://ojs.tdmu.edu.ua/index.php/pharm-chas/article/view/6058
10.11603/2312-0967.2016.1.6058 |
|
| Source |
Pharmaceutical Review; № 1 (2016)
Фармацевтичний часопис; № 1 (2016) 2414-9926 2312-0967 10.11603/2312-0967.2016.1 |
|
| Language |
ukr
|
|
| Relation |
http://ojs.tdmu.edu.ua/index.php/pharm-chas/article/view/6058/5551
|
|
| Rights |
##submission.copyrightStatement##
|
|