Genetic determinism of the functional condition of the endothelium in patients with chronic diffuse liver disease and disoders of thyroid homeostasis
Цифровий Репозиторій - Інтелектуальні Фонди Буковинського державного медичного університету
Переглянути архів Інформація| Поле | Співвідношення | |
| Title |
Genetic determinism of the functional condition of the endothelium in patients with chronic diffuse liver disease and disoders of thyroid homeostasis
|
|
| Creator |
Chympoy, K.A.
Pashkovska, N.V. Garasdyuk, O.I. Pavlyukovich, N.D. |
|
| Subject |
сhгоniс diffuse liver disease
thyroid homeostasis polymorphism endothelium хронические диффузные заболевания печени тиреоидный гомеостаз полиморфизм эндотелий хронічні дифузні захворювання печінки тиреоїдний гомеостаз поліморфізм ендотелій |
|
| Description |
Patients with chronic diffuse of liver disease have a violation of thyroid homeostasis in the form of reduction of free triiodothyronine in the blood serum, as well as thyroid stimulating hormone increasing content and of free thyroxin. In patients with chronic diffuse liver diseases there is a relation between the expression of Pro197Leu polymorphism of GPX1 gene and indices of cellular adhesion, which is revealed by a reliably higher content of soluble intercellular adhesion molecule type 1 in the blood serum in homozygotic carriers of Leu-allele. Changes of the endothelial functional state in patients with chronic diffuse liver diseases are associated with Pro197Leu polymorphism of GPX1 gene, which is proved by a reliably higher index of desquamated endotheliocytes amount and lower level of nitric oxide metabolites in the carriers of LeuLeu-genotype. |
|
| Date |
2016-05-26T09:35:31Z
2016-05-26T09:35:31Z 2014 |
|
| Type |
Article
|
|
| Identifier |
http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/10882
|
|
| Language |
en
|
|
| Format |
application/pdf
|
|
| Publisher |
Міжнародний ендокринологічний журнал. – 2014. – №1(57). – С.53-56.
|
|