Effect of DIO1 and GPX1 gene polymorphism on the functional condition of the endothelium in patients with chronic diffuse liver disease
Цифровий Репозиторій - Інтелектуальні Фонди Буковинського державного медичного університету
Переглянути архів Інформація| Поле | Співвідношення | |
| Title |
Effect of DIO1 and GPX1 gene polymorphism on the functional condition of the endothelium in patients with chronic diffuse liver disease
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| Creator |
Chympoy, K.A.
Pashkovska, N.V. Olinyk, O.Ju. Teleki, Ja.M. |
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| Subject |
chronic diffuse liver diseases
хронические диффузные заболевания печени хронічні дифузні захворювання печінки gene polymorphism endothelium полиморфизм гена эндотелий поліморфізм гену ендотелій |
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| Description |
In patients with chronic diffuse liver diseases there is a relation between the expression of Pro197Leu polymorphism of GPX1 gene and indices of cellular adhesion, which is revealed by a reliably higher content of soluble intercellular adhesion molecule-1 type in the blood serum in homozygotic carriers of Leu-allele. Changes of the endothelial functional state in patients with chronic diffuse liver diseases are associated with Pro197Leu polymorphism of GPX1 gene, which is proved by a reliably higher index of desquamated endotheliocytes amount and lower level of NO metabolites in the carriers of LeuLeu-genotype. Examination of the indices of cellular adhesion and functional endothelial state in patients with chronic diffuse liver diseases did not reveal their dependence on the distribution of A/C polymorphism of DIO1 gene.
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| Date |
2016-06-08T09:54:09Z
2016-06-08T09:54:09Z 2015 |
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| Type |
Article
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| Identifier |
http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/10994
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| Language |
en
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| Format |
application/pdf
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| Publisher |
International scientific-practical congress of pedagogues, psychologists and medics (5 th June, 2015, Geneva). – P. 231-238.
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