COMPARATIVE ANALYSIS OF TABLETS OF DIFFERENT SERIES AND REFERENCE DRUG ON THE GROUND OF THE SUBSTANCE ADEMETIONINE 1,4-BUTANDISULFONATE BY INFRARED SPECTROSCOPY
Наукові журнали Тернопільського державного медичного університету імені І.Я.Горбачевського
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COMPARATIVE ANALYSIS OF TABLETS OF DIFFERENT SERIES AND REFERENCE DRUG ON THE GROUND OF THE SUBSTANCE ADEMETIONINE 1,4-BUTANDISULFONATE BY INFRARED SPECTROSCOPY
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Burdak, K. S.; Тернопільський державний медичний університет, Тернопіль
Yarnyh, T. H. Borshchevska, M. I. Yanchuk, I. B. |
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| Description |
COMPARATIVE ANALYSIS OF TABLETS OF DIFFERENT SERIES AND REFERENCE DRUG ON THE GROUND OF THE SUBSTANCE ADEMETIONINE 1,4-BUTANDISULFONATE BY INFRARED SPECTROSCOPYK.S. Burdak 1, T.H.Yarnyh2, M.I.Borshchevska1, I.B. Yanchuk11JSC "Farmak", Kyiv, Ukraine 2National University of Pharmacy, Kharkiv, UkraineIntroductionInfrared analysis – is a universal physial method that is applied in the research of structural features of different organic and inorganic compounds. Its peculiarity is possibility to carry out the research without previous sample processing that is very important during the work with moisture-retentive chemicals. During the molecule is irradiated by infrared light only those quanta are absorbed frequency of which agree with frequency of valence, deformational and vibrational motion of the molecules [2,3].Investigation methodsWere studied: lot 20515 (pattern №1 that was got under the environmental humidity of 15%), lot 10314 (pattern №2, environmental humidity 20%), lot 10513 (pattern №3, environmental humidity 30%) and lot 11113 (pattern №4, environmental humidity 40%).Received pills were being investigated with the help of absorption infrared spectroscopy (AIR spectroscopy) in the intermediate infrared band (4000-400 cm-1). During the researches apparatus Thermo Nicolet IS50 with ATR module.Results and discussionsThis way, in accordance with the results of our researches the mechanisms of transformation of ademetionine structure under the influence of water or –OH groups. Received data confirm that optimized climatic conditions for the production of pills on the basis of the substance ademetionine 1,4 butandisulfonate is environmental humidity not higher than 20%, and the temperature 20 °С.1. ConclusionsComparative analysis of ademetionine 1,4 butandisulfonate pills of different series and reference listed drug «Heptral» was carried out with the help of infrared spectroscopy.It is shown that infrared absorption spectroscopy as operational method of the analysis allows to study the influence of the humidity on structural-informative qualities of the substance ademetionine 1,4 butandisulfonate in developing preparations.It’s experimentally determined and confirmed that optimized climatic parameters of getting pills, environmental humidity not higher than 20% and the temperature 20°С.ReferencesIssledovanie fiziko-himicheskih vzaimodeystviy v tverdoy faze mezhdu komponentami preparatov analgeziruyuschego, protivovospalitelnogo i zharoponizhayuschego deystviya na osnove paratsetamola / N. O.Eltsova, G. B. Golubitskiy, E. V. Budko, O. I. Izosimin. // Mezhdunarodnyiy zhurnal prikladnyih i fundamentalnyih issledovaniy. – 2014. – #3. – S. 118–123.Identification of anisodamine tablets by Raman and near-infrared spectroscopy with chemometrics / [L. Li, J. Li, H. Zang та ін.]. // Spectrochimica Acta Part A: Molecular Spectroscopy. – 2015. – №127. – С. 91 – 97.Chaveza P. Active content determination of pharmaceutical tablets using near infrared spectroscopy as Process Analytical Technology tool / P. Chaveza, P. Sacréa. // Talanta. – 2015. – №144. – С. 1352–1359.Frank S. Identification of a pharmaceutical tablet’s origin using FT Near-IR and Principal Component Analysis / S. Frank, M. S. Weston. // Agilent Technologies. – 2011. – С. 1–10.Priboryi dlya farmatsevticheskogo analiza. // Farmatsevticheskaya otrasl. – 2012. – #4. – S. 104–106.
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Тернопільський державний медичний університет ім. І.Я. Горбачевського
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2016-07-08
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info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion — |
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application/msword
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| Identifier |
http://ojs.tdmu.edu.ua/index.php/pharm-chas/article/view/6648
10.11603/2312-0967.2016.2.6648 |
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Pharmaceutical Review; № 2 (2016)
Фармацевтичний часопис; № 2 (2016) 2414-9926 2312-0967 10.11603/2312-0967.2016.2 |
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ukr
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http://ojs.tdmu.edu.ua/index.php/pharm-chas/article/view/6648/6062
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