In vitro study of NCs/dyes complexes accumulation and dyes release kinetics in rat hepatocytes
Vernadsky National Library of Ukraine
Переглянути архів Інформація| Поле | Співвідношення | |
| Title |
In vitro study of NCs/dyes complexes accumulation and dyes release kinetics in rat hepatocytes
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| Creator |
Yefimova, S.L.
Tkacheva, T.N. Kavok, N.S. Klochkov, V.K. Sorokin, A.V. |
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| Subject |
Characterization and properties
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| Description |
Using fluorescence microspectoscopy and FRET-labeling of various nano-scale carriers (NCs) the efficiency and kinetics of NCs/dye molecules complexes accumulation in living cells and dye release have been studied. Organic liposome vesicles and inorganic nanoparticles (CeO₂ and GdYVO₄:Eu³⁺) were used as NCs. NCs/dyes complexes formed in aqueous solutions have been characterized. It has been shown that NCs based on GdYVO₄:Eu³⁺ nanoparticles exhibit the most effective accumulation in cells and provide very fast release of the lipophilic cargo (dyes molecules). Lipophilic compound (cholesterol) embedded into the NCs/dyes complexes decreases noticeably the rate of lipophilic dyes release and reduces the affinity of the complex interaction with hepatocytes. GdYVO₄:Eu³⁺ NPs could be used as a nano-scale platform for controlled intracellular delivering of hydrophobic agents.
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| Date |
2017-06-06T14:34:41Z
2017-06-06T14:34:41Z 2015 |
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| Type |
Article
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| Identifier |
In vitro study of NCs/dyes complexes accumulation and dyes release kinetics in rat hepatocytes / S.L. Yefimova, T.N. Tkacheva, N.S. Kavok, V.K. Klochkov, A.V. Sorokin// Functional Materials. — 2015. — Т. 22, № 2. — С. 199-206. — Бібліогр.: 31 назв. — англ.
1027-5495 DOI: http://dx.doi.org/10.15407/fm22.02.199 http://dspace.nbuv.gov.ua/handle/123456789/119352 |
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| Language |
en
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| Relation |
Functional Materials
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| Publisher |
НТК «Інститут монокристалів» НАН України
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