ASSOCIATION OF A313G POLYMORPHISM OF GSTP1 GENE WITH BIOCHEMICAL BLOOD PARAMETERS IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE
Цифровий Репозиторій - Інтелектуальні Фонди Буковинського державного медичного університету
Переглянути архів Інформація| Поле | Співвідношення | |
| Title |
ASSOCIATION OF A313G POLYMORPHISM OF GSTP1 GENE WITH BIOCHEMICAL BLOOD PARAMETERS IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE
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| Creator |
Prysyazhnyuk, V.P.
Sydorchuk, L.P. |
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| Subject |
nonalcoholic fatty liver disease
glutathione-S- transferase gene polymorphism неалкогольна жирова хвороба печінки ген глутатіон-S-трансферази поліморфізм |
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| Description |
Background: One of the key gene involved in chronic diffuse liver diseases pathogenesis, including nonalcoholic fatty liver disease are genes encoding the synthesis of glutathione-S-transferases. The objective of the study was to investigate a possible link between A313G polymorphism of the GSTP1 gene and biochemical blood parameters in nonalcoholic fatty liver disease patients. Methods: Gene polymorphism of GSTP1 (A313G) in 64 non-alcoholic fatty liver disease patients and 20 healthy individuals (control group) was studied. The range of investigated biochemical blood parameters included: total bilirubin and its fractions, cholesterol, triglycerides, uric acid, total protein and albumin, urea, creatinine, plasma enzyme activity. Results: G-allele significantly more frequently by 2.47 times (OR = 2.47, CI = 1.01-6.03, p<0.05) occurred in observed patients compared with healthy individuals. Total bilirubin level in blood of patients with GG-genotype was by 19.7% (p = 0.03) and by 36.9% (p = 0.04) higher compared with AA-genotype and AG-genotype carriers respectively. Presence of G-allele was associated with increased alanine aminotransferase activity, which was significantly higher in observed patients AG- and GG-genotypes carriers compared to patients with-AA genotype at 60.7% (p =0.03) and 51.0% (p = 0.04) respectively. Conclusions: Frequency of G-allele of GSTP1 gene was in 2.47 times (OR = 2.47, CI = 1.01-6.03, p<0.05) higher in nonalcoholic fatty liver disease patients compared with healthy individuals in Ukrainian population. Presence of G-allele was associated with increased concentration of total bilirubin and higher activity of cytolytic syndrome in observed patients. Кафедра пропедевтики внутрішніх хвороб |
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| Date |
2017-09-05T07:08:57Z
2017-09-05T07:08:57Z 2016-06 |
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| Type |
Article
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| Identifier |
http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/12704
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| Language |
en
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| Format |
application/pdf
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| Publisher |
Archives of the Balkan Medical Union vol. 51, no. 2, pp. 178-182.
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