Significance of certain genotypic characteristics to form exercise-induced bronchial asthma in children
Цифровий Репозиторій - Інтелектуальні Фонди Буковинського державного медичного університету
Переглянути архів Інформація| Поле | Співвідношення | |
| Title |
Significance of certain genotypic characteristics to form exercise-induced bronchial asthma in children
|
|
| Creator |
Кoloskova, O.K.
Bilous, Т.М. Lomakina, Y.V. |
|
| Subject |
children
exerciseinducedbronchialasthma genepolymorphism |
|
| Description |
Accordingtoatopicalup-to-datedefinitionsuggestedinPRACTALL [1], exercise-inducedbronchialasthma (EIBA) isaseparatevariantofbronchialasthma (BA) whentransientbronchialobstructionassociatedwithphysicalactivityisdetected. ItsoccurrenceinchildrenwithoutBAisdeterminedas “bronchialspasm” or “exercise-inducedbronchialconstriction”[2, 3]. Exercise-inducedbronchialspasm (EIBS) isobjectivelydeterminedas10% reductionofFEV1 (forcedexpiratoryvolumein 1 second) andmorethanthatoftheinitialvalueafterappropriatebronchialprovocationtest[4, 5]. AlthoughthemostfrequenttriggerofEIBAisintensiveandrelativelylongphysicalactivity, thisdiseaseischaracterizedbyamulti-triggercharacterofexacerbationsalteringthecourseofBAintomoresevereone[6]. According to these authors in addition to physical activity the following triggers of BA are: meteorological factors (32,9%), acute respiratory viral infection (ARVI) of effect of cold (22,3%), pollen (19,0%), animal epidermis (14,4%), house dust (11,0%), and exposure to tobacco smoke (8,0%). AtthesametimetherearecertaindataprovingtheroleofageneticcomponentinthedevelopmentofBAasamultifactorialdisease[7-8]. These investigations deal with the study of the role of deletion gene polymorphism coding the activity of glutathione-S-transferase for the course of BA in children [9-10]. Atthesametime, itshouldbenotedthatpathogenesisofBAphenotypehasnotbeenstudiedcompletelyyet, whichisevidentinunsolvedquestionsofdiagnosticsandindividualizedapproachestotreatment. Modernscientificliteratureavailabledoesnotpresentsufficientevidenceconcerningthevalueofgeneticcomponent, anddeletionsofGSTT1andGSTM1 genesin particular, and/or mutation polymorphism of еNOSgene in the formation of exercise-induced bronchial spasm. |
|
| Date |
2017-10-18T11:18:17Z
2017-10-18T11:18:17Z 2017 |
|
| Type |
Article
|
|
| Identifier |
1512-2778
http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/13032 |
|
| Language |
en
|
|
| Relation |
Vol. 13, N. 1.;
|
|
| Format |
application/pdf
|
|
| Publisher |
Georgian Respiratory Journal
|
|