Gender-specific differences of bronchial asthma phenotypes in children depending on puberty status
Цифровий Репозиторій - Інтелектуальні Фонди Буковинського державного медичного університету
Переглянути архів Інформація| Поле | Співвідношення | |
| Title |
Gender-specific differences of bronchial asthma phenotypes in children depending on puberty status
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| Creator |
Chandarana, N.,
Bogutska, N.K. |
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| Subject |
asthma phenotypes,
children, gender, puberty. |
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| Description |
Further investigations are needed to examine the effect of gender-specific differences in changes of asthma prevalence and phenotypes in pre- and post puberty. Objective of the study was to evaluate if sex-based differences exist in clinical and epidemiologic characteristics of asthma in children before and after puberty. The research assignments: 1. To study the peculiarities of clinical phenotypes of BA in children depending on gender in pre- and post-puberty. 2. To investigate the detailed data of bronchial asthma manifestations (birth weight and body mass index, familial allergic anamnesis and allergic skin tests, serum IgE, bronchial lability index and airways hyperresponsiveness index, type of acetylation) in males and females before and after puberty onset. Material and methods. 120 children of 6-18 years old of both sexes with at least one year duration of persistent bronchial asthma were examined. The first (I) group included 49 patients with persistent BA before puberty, the second (II) clinical group was formed of 71 patients with diagnosis of persistent BA after puberty onset. No significant differences by sex, age, and place of residence have been shown due to correctly formed clinical groups of comparison. The clinico-anamnestic, allergologic, spirometric and statistical methods of research were used. Results and discussion. In the examined cohort late onset BA phenotype (debut after 6 years old) predominated regardless of gender and puberty status, first of all in post-pubertal females as compared to pre-puberty period (RR=1,3; 95%CI:0,6-3,0). Such association may be explained by tendency of increasing BA prevalence in girls with aging as well as with BA under diagnosing (Yentl syndrome). Early onset BA (up to 3 years old) non significantly associated with male gender before puberty. Non-severe BA diagnosing predominated in pre-puberty period both in girls and boys, but post-puberty period both in females and males associated with non significantly increased risk of severe BA phenotype as compared to alternative asthma variant (RR=1,6; 95%CI:0,5-5,1 and RR=1,4; 95%CI:0,8-2,5 respectively). Atopic (allergic) BA predominated in males regardless of puberty status, as well as non-atopic phenotype associated with female gender both in pre- and postpuberty. Exercise induced asthma (phenotype with exercise induced bronchoconstriction) was almost equally distributed among both sexes regardless of puberty status. Futhermore, such atopic manifestations as max skin papula to one of the epidermal allergens and genealogic index of positive allergic familial anamnesis significantly predominated in males as compared to females in pre – and post-puberty respectively. No any significant differences of the spirometric indices were revealed in groups of children depending on gender and puberty status. Females tended to have lower birth weight as compared to males regardless of puberty status and no differences of actual BMI in groups of comparison were revealed. After puberty risk of hospitalization to emergency department due to BA exacerbation in males significantly decreased as compared to pre-puberty period (RR=0,6; 95%CI:0,4-0,8) and in females such risk slightly increased in post-puberty (RR=1,4; 95%CI:0,7-2,7). Conclusions. Late onset asthma phenotype with debut after 6 years old non significantly predominated in children, first of all in post-pubertal females, while early onset asthma (up to 3 years old) associated with male gender before puberty. Non-severe asthma diagnosing predominated in pre-puberty period, but post-puberty period associated with slightly increased risk of severe asthma phenotype. After puberty risk of hospitalization to emergency department due to asthma exacerbation in boys significantly decreased and in girls such risk slightly increased. Non-atopic asthma phenotype associated with female gender, while atopic (allergic) asthma predominated in males regardless of puberty status. |
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| Date |
2017-10-19T10:48:45Z
2017-10-19T10:48:45Z 2017 |
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| Type |
Article
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| Identifier |
http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/13109
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| Language |
en
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| Format |
application/pdf
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| Publisher |
Фундаментальная наука в современной медицине 2017 : материалы сателл. дистанцион. науч.-практ. конф. студентов и молодых ученых, Минск, 3 марта 2017 г. / Белорус. гос. мед. ун-т ; под ред. А. В. Сикорского [ и др.]. - Минск : БГМУ, 2017
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