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Structural fluctuations and aging processes in deeply frozen proteins

Vernadsky National Library of Ukraine

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Title Structural fluctuations and aging processes in deeply frozen proteins
 
Creator Schlichter, J.
Ponkratov, V.V.
Friedrich, J.
 
Subject Biological Systems at Low Temperatures
 
Description Frozen proteins are nonergodic systems and are subject to two types of structural motions, namely relaxation and fluctuation. Relaxation manifests itself in aging processes which slow the fluctuations. Within certain approximations we are able to experimentally separate the aging dynamics from the fluctuation dynamics by introducing two time parameters, namely an aging time ta and a waiting time tw. Both processes follow power laws in time. The fluctuation dynamics shows features of universality characterized by a rather uniform exponent of 1/4. This universality features were shown to be possible due to a random walk on a 1D random trajectory in conformational phase space. A very interesting aspect of protein dynamics concerns the influence of the host solvent on structural motions of the protein cores. We present results for sugar solvents and discuss possible mechanisms.
 
Date 2018-01-14T13:04:47Z
2018-01-14T13:04:47Z
2003
 
Type Article
 
Identifier Structural fluctuations and aging processes in deeply frozen proteins / J. Schlichter, V.V. Ponkratov, J. Friedrich // Физика низких температур. — 2003. — Т. 29, № 9-10. — С. 1049-1056. — Бібліогр.: 21 назв. — англ.
0132-6414
PACS: 87.15.-v
http://dspace.nbuv.gov.ua/handle/123456789/128929
 
Language en
 
Relation Физика низких температур
 
Publisher Фізико-технічний інститут низьких температур ім. Б.І. Вєркіна НАН України