THE EFFECT OF NADP ON SOME VALUES OF THE RENAL SECRETORY FUNCTION IN RATS WITH STREPTOZOTOCININDUCED DIABETES MELLITUS
Цифровий Репозиторій - Інтелектуальні Фонди Буковинського державного медичного університету
Переглянути архів Інформація| Поле | Співвідношення | |
| Title |
THE EFFECT OF NADP ON SOME VALUES OF THE RENAL SECRETORY FUNCTION IN RATS WITH STREPTOZOTOCININDUCED DIABETES MELLITUS
ВПЛИВ НАДФ НА ОКРЕМІ ПОКАЗНИКИ ЕКСКРЕТОРНОЇ ФУНКЦІІ НИРОК ПРИ СТРЕПТОЗОТОЦИНІНДУКОВАНОМУ ЦУКРОВОМУ ДІАБЕТІ У ЩУРІВ |
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| Creator |
Грицюк, Мар'яна Іванівна
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| Subject |
diabetes mellitus
nephropathу hyperfiltration streptozotocin diuresis цукровий діабет нефропатія гіперфільтрація стрептозотоцин діурез |
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| Description |
Diabetes has been a significant social problem, since it leads both to disability and mortality. The experiment involved 32 sexually mature nonlinear males of white rats. Experimental groups of animals were administered a single streptozotocin dose of 70 mg/ kg intraperitoneally and NADP — 30 mg/kg. The animals in the experimental groups were slaughtered and studied on the 11th, 21st and 31st days after streptozotocin administration. The studies have shown that, along with the development of proteinuria, kidney damage is manifested by the primary increase in glomerular filtration rate and changes in diuresis in experimental animals. Conclusion. The primary possible mechanisms of the development of diabetic nephropathy are the disorders in glycosylation processes, overload of functioning nephrons with protein, and increasing energy expenditure in the proximal and distal parts of the nephron. |
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| Date |
2018-03-09T03:05:55Z
2018-03-09T03:05:55Z 2017 |
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| Type |
Article
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| Identifier |
ISSN 1818-9385
http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/13519 |
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| Language |
en
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| Relation |
;UDC 616.632/.633: 615.015.4: 577.15.013: 616.379-008.64
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| Format |
application/pdf
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| Publisher |
Актуальні питання транспортної медицини: навколишнє середовище; професійне здоров’я; патологія. № 4 (50), 2017. С. 106-110.
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