Effect of pro197leu polymorphism of the gene GPX 1 on functional state of endothelium indices of patients with metabolic syndrome
Цифровий Репозиторій - Інтелектуальні Фонди Буковинського державного медичного університету
Переглянути архів Інформація| Поле | Співвідношення | |
| Title |
Effect of pro197leu polymorphism of the gene GPX 1 on functional state of endothelium indices of patients with metabolic syndrome
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| Creator |
Abramova, N.O.
Pashkovska, N.V. |
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| Subject |
Pro197Leu polymorphism of GPX 1 gene
the functional state of the endothelium vascular endothelial growth factor endotheliocytes metabolic syndrome Pro197Leu полиморфизм гена GPX 1 функциональное состояние эндотелия сосудистый эндотелиальный фактор роста эндотелиоциты метаболический синдром Pro197Leu поліморфізм гена GPX 1 функціональний стан ендотелію судинний ендотеліальний фактор росту ендотеліоцити метаболічний синдром |
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| Description |
Pro197Leu polymorphism of the gene GPX 1 has been studied in 102 patients with MS and 97 healthy individuals. Disorders of genotype frequencies distribution comparing with the control group at the expense of the reduction of Pro/Pro genotype frequency have been found in the main group (ð < 0,05). Assessment of the relative risk was carried by odds ratio (OR) magnitude. The OR calculation showed the growth of risk of GPX 1 activity disorder in patients with Pro/Leu and Leu/Leu variants of polymorphism comparing with homozygous for the Pro-allele at 4,7 and 6,9 times respectively (ð < 0,05). Individuals with Leu/Leu genotype had significantly higher level of VEGF and endothelial desquamation intensity as compared with the persons with Pro/Pro genotype (ð < 0,05). Consequently, Pro-allele has protective properties, it means that presence of these allele in genotype reduses risk of glutathione peroxidase activity decreasing. In Leu-allele carriers, activity of GPX 1 decreases, free radicals accumulate, that cause lipid peroxidation and activation of transcription factors, followed by increasing expression of cytokines, which are also directly affect the endothelium.
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| Date |
2018-05-24T10:29:57Z
2018-05-24T10:29:57Z 2014 |
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| Type |
Article
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| Identifier |
UDC 616-008.9:616.441]-092-08
http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/13839 |
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| Language |
en
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| Format |
application/pdf
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| Publisher |
Клінічна та експериментальна патологія
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