Amplification and co-regulators of androgen receptor gene in prostate cancer
Vernadsky National Library of Ukraine
Переглянути архів Інформація| Поле | Співвідношення | |
| Title |
Amplification and co-regulators of androgen receptor gene in prostate cancer
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| Creator |
Golias, Ch.
Iliadis, I. Peschos, D. Charalabopoulos, K. |
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| Subject |
Reviews
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| Description |
Prostate cancer isthe second most common malignancy among males after lung cancer. The growth of prostate cancer cells depends on the presence of androgens, a group ofsteroid hormones that include testosterone and its more active metabolite dihydrotestosterone. Most prostate cancers are androgen-dependent and respond to the antiandrogens or androgen-deprivation therapy. However, the progression to an androgen-independent stage occurs frequently. Possible mechanisms that could be involved in the development of hormone resistant prostate cancer causes including androgen receptor (AR) mutations, AR amplification/over expression, interaction between AR and other growth factors, and enhanced signaling in a ligand-independent manner are discussed. |
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| Date |
2018-06-14T11:37:00Z
2018-06-14T11:37:00Z 2009 |
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| Type |
Article
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| Identifier |
Amplification and co-regulators of androgen receptor gene in prostate cancer / Ch. Golias, I. Iliadis, D. Peschos, K. Charalabopoulos // Experimental Oncology. — 2009. — Т. 31, № 1. — С. 3-8. — Бібліогр.: 46 назв. — англ.
1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/134927 |
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| Language |
en
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| Relation |
Experimental Oncology
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| Publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
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