Nuclear receptors and their role in epstein — barr virus induced b cell transformation
Vernadsky National Library of Ukraine
Переглянути архів Інформація| Поле | Співвідношення | |
| Title |
Nuclear receptors and their role in epstein — barr virus induced b cell transformation
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| Creator |
Yenamandra, S.P.
Klein, G. Kashuba, E. |
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| Subject |
Reviews
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| Description |
Epstein — Barr virus (EBV) is a lymphotropic virus that infects more than 90% of the human population, and targets B cells for infection. Infection of human B cells leads to the malignant transformation and eventual immortalization. In latency III infection six EBV-encoded nuclear antigens (EBNAs) and three latent membrane proteins (LMPs) are expressed in the transformed cells that can grow as a lymphoblastoid cell lines in vitro. These proteins hijack the normal B cell growth pathways by activating the constitutive growth promotion and external survival signals. We have determined a set of the nuclear receptors that are up- (and down-) regulated in the latency III infected cells at the mRNA level. In the present paper we discussed the possible role of these receptors in B cell transformation upon EBV infection based on the literature data. |
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| Date |
2018-06-15T14:00:35Z
2018-06-15T14:00:35Z 2009 |
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| Type |
Article
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| Identifier |
Nuclear receptors and their role in epstein — barr virus induced b cell transformation / S.P. Yenamandra, G. Klein, E. Kashuba // Experimental Oncology. — 2009. — Т. 31, № 2. — С. 67-73. — Бібліогр.: 81 назв. — англ.
1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/135697 |
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| Language |
en
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| Relation |
Experimental Oncology
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| Publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
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