Expression of cathepsin l in nasopharyngeal carcinoma and its clinical significance
Vernadsky National Library of Ukraine
Переглянути архів Інформація| Поле | Співвідношення | |
| Title |
Expression of cathepsin l in nasopharyngeal carcinoma and its clinical significance
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| Creator |
Xu, X.
Yuan, G. Liu, W. Zhang, Y. Chen, W. |
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| Subject |
Original contributions
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| Description |
Aim: To study the expression of cathepsin L in nasopharyngeal carcinoma (NPC), and analyze its relationship with clinicopathologic factors. Methods: The expression of cathepsin L was determined immunohistochemically in NPC, adjacent normal nasopharyngeal tissues and metastatic cervical lymph nodes. The correlation between its protein expression and clinicopathologic parameters as well as with long term follow-up data in NPC was analyzed. Results: The protein of cathepsin L was overexpressed in 47% primary tumor tissues, and in 89% metastatic cervical lymph node samples. Overexpression of cathepsin L was found to correlate with lymph node metastasis (P = 0.04) and distant metastasis (P = 0.01), and marginally with clinical stage and T classification, but not with patient age, gender and histological classification of tumor. Patients with overexpression of cathepsin L in tumor tissue had worse 5-year survival than those without such expression pattern (P= 0.033). Multivariate survival analysis showed that cathepsin L protein expression level had a marginal significant correlation with prognosis of NPC. Conclusion: Cathepsin L is a potential biomarker for prognosis of NPC and contributes to NPC metastasis. |
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| Date |
2018-06-15T13:59:40Z
2018-06-15T13:59:40Z 2009 |
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| Type |
Article
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| Identifier |
Expression of cathepsin l in nasopharyngeal carcinoma and its clinical significance / X. Xu, G. Yuan, W. Liu, Y. Zhang, W. Chen // Experimental Oncology. — 2009. — Т. 31, № 2. — С. 102-105. — Бібліогр.: 19 назв. — англ.
1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/135696 |
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| Language |
en
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| Relation |
Experimental Oncology
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| Publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
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