Analysis of in vitro and in vivo sensitivity of oral cancer cells to methotrexate
Vernadsky National Library of Ukraine
Переглянути архів Інформація| Поле | Співвідношення | |
| Title |
Analysis of in vitro and in vivo sensitivity of oral cancer cells to methotrexate
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| Creator |
Pai, R.B.
Lalitha, R.M. Pai, S.B. Kumaraswamy, S.V. Lalitha, N. Bhargava, M.K. |
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| Subject |
Short communications
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| Description |
Aim: The present study was directed on the assessment of the response of treatment-naive oral cancer cells to methotrexate (MTX) in vitro and clinical response to MTX therapy. Methods: A pilot study of in vitro evaluation of MTX response of oral cancer cells from 10 patients was conducted using a cell viability assay to determine the sensitivity/resistance to MTX. Quantitative in vitro data were correlated to the clinical outcome to MTX therapy. Results: A positive correlation was observed between the effect of MTX on tumor cells in vitro and clinical response for 7 out of 10 patients. Conclusions: Observations from the proof-of-principle pilot study suggests that oral cancer cells have intrinsically variable response toMTX. Confirmation ofthese findings with a larger cohort of patients could aid in the development of individualized therapies for this class of malignancy. |
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| Date |
2018-06-15T14:18:34Z
2018-06-15T14:18:34Z 2009 |
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| Type |
Article
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| Identifier |
Analysis of in vitro and in vivo sensitivity of oral cancer cells to methotrexate / R.B. Pai, R.M. Lalitha, S.B. Pai, S.V. Kumaraswamy, N. Lalitha, M.K. Bhargava // Experimental Oncology. — 2009. — Т. 31, № 2. — С. 118–120. — Бібліогр.: 14 назв. — англ.
1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/135717 |
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| Language |
en
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| Relation |
Experimental Oncology
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| Publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
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