The level of IgG antibodies reactive to TF, Tn and Alpha-Gal polyacrylamide-glycoconjugates in breast cancer patients: relation to survival
Vernadsky National Library of Ukraine
Переглянути архів Інформація| Поле | Співвідношення | |
| Title |
The level of IgG antibodies reactive to TF, Tn and Alpha-Gal polyacrylamide-glycoconjugates in breast cancer patients: relation to survival
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| Creator |
Smorodin, E.P.
Sergeyev, B.L. |
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Original contributions
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| Description |
Background: The serum levels of IgG antibodies reactive to glycoconjugates (TF, Tn and αGal) were found to be associated with prognosis of gastrointestinal cancer patients. Aim: To study the relation between the levels of serum antibodies to TF-pAA, Tn-PAA and αGal-PAA polyacrylamide-based glycoconjugates and survival in breast cancer. Materials and Methods: The preoperative level of IgG antibodies was analysed in the serum of patients (n = 59) using ELISA with polyacrylamide-glycoconjugates namely, TF-pAA (amide-type), and ethanolamide-conjugates Tn-PAA and αGal-PAA. Survival rate and hazard ratio (HR) were assessed by the Kaplan — Meier method and Cox univariate analysis in different pathomorphological groups. Results: Significantly better survival was observed in patients with an increased level of anti-TF-pAA antibodies both for all patients in total and groups in stages II–III; N1–2 and G3 (p = 0.008–0.021, HR = 0.18–0.23, mean survival time in months 164–186 vs 69–121). A trend to worse survival was observed in increased level of anti-Tn IgG (stages II–III) and anti-αGal IgG (G3): p = 0.075, HR = 2.49 and p = 0.066, HR = 3.27, respectively. Conclusion: The method for the determination of circulating anti-TF-pAA IgG may be a useful supplement in long-term prognostic assessment of patients with breast cancer.
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| Date |
2018-06-17T20:26:46Z
2018-06-17T20:26:46Z 2016 |
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| Type |
Article
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| Identifier |
The level of IgG antibodies reactive to TF, Tn and Alpha-Gal polyacrylamide-glycoconjugates in breast cancer patients: relation to survival / E.P. Smorodin, B.L. Sergeyev // Experimental Oncology. — 2016 — Т. 38, № 2. — С. 117-121. — Бібліогр.: 31 назв. — англ.
1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/137989 |
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| Language |
en
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| Relation |
Experimental Oncology
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| Publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
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