Experimental study of antiangiogenic and photodynamic therapies combination for treatment of peritoneal carcinomatosis: preliminary results
Vernadsky National Library of Ukraine
Переглянути архів Інформація| Поле | Співвідношення | |
| Title |
Experimental study of antiangiogenic and photodynamic therapies combination for treatment of peritoneal carcinomatosis: preliminary results
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| Creator |
Piatrouskaya, N.A.
Kharuzhyk, S.A. Vozmitel, M.A. Mazurenko, A.N. Istomin, Y.P. |
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Original contributions
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| Description |
Aim: To create adequate orthotopic model of peritoneal carcinomatosis in rats using a transplantable rat tumor M-1 sarcoma, to assess the early tumor response after intraperitoneal photodynamic and/or antiangiogenic therapy for peritoneal carcinomatosis. Methods: In 14–18 days after intraperitoneal inoculation, eighteen tumor-bearing animals were divided into three groups and undergone intraperitoneal photodynamic therapy and/or antiangiogenic therapy. Assessment of the tumor posttreatment changes was performed using a method of vital staining with Evans blue, MRI-monitoring and morphologic investigation. Results: Percentage of necrosis in disseminated tumors of animals undergone combination therapy significantly higher then after each of the methods alone and achieved 89.46% vs 41.47% after antiangiogenic therapy and 69.73% after photodynamic therapy. Contrast-enhanced MRI showed entirely necrotic tumor nodes in rats undergone the combination therapy. Morphologic study confirmed that tumor response after combination therapy was characterized by maximal spread of necrotic and inflammatory changes in tumor. Conclusion: Preliminary results demonstrate enhance of the treatment outcome after combination of antiangiogenic and intraperitoneal photodynamic therapies for peritoneal carcinomatosis in rats.
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| Date |
2018-06-19T10:22:18Z
2018-06-19T10:22:18Z 2010 |
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| Type |
Article
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| Identifier |
Experimental study of antiangiogenic and photodynamic therapies combination for treatment of peritoneal carcinomatosis: preliminary results / N.A. Piatrouskaya, S.A. Kharuzhyk, M.A. Vozmitel, A.N. Mazurenko, Y.P. Istomin // Experimental Oncology. — 2010. — Т. 32, № 2. — С. 100-103. — Бібліогр.: 14 назв. — англ.
1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/138601 |
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en
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| Relation |
Experimental Oncology
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
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