Distribution and accumulation of liposomal form of doxorubicin in breast cancer cells of MCF-7 line
Vernadsky National Library of Ukraine
Переглянути архів Інформація| Поле | Співвідношення | |
| Title |
Distribution and accumulation of liposomal form of doxorubicin in breast cancer cells of MCF-7 line
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| Creator |
Rusetskaya, N.V.
Khariton, N. Yurchenko, O.V. Chekhun, V.F. |
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Original contributions
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| Description |
Aim: To study distribution and accumulation of liposomal form of doxorubicin in human breast cancer cells of MCF-7 line and Dox-resistant subline MCF-7/Dox. Methods: High performance liquid chromatography and laser confocal microscopy were used. Results: It has been shown that conventional form of doxorubicin was more efficiently delivered to the MCF-7 cells already after 30 min of incubation amounting to its maximum concentration after 4 h. MCF-7/Dox cells are characterized by lower doxorubicin accumulation rate compared with parental cells. The quantity of accumulated liposomal form of doxorubicin is high in MCF-7 cells, and, what is important, Dox-resistant cells accumulated higher levels of liposomal form of doxorubicin than its conventional form. Conclusion: It has been shown that intracellular distribution and accumulation of liposomal forms of doxorubicin in parental and Dox-resistant MCF-7 cells differs from that of conventional doxorubicin.
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| Date |
2018-06-19T10:40:04Z
2018-06-19T10:40:04Z 2011 |
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| Type |
Article
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| Identifier |
Distribution and accumulation of liposomal form of doxorubicin in breast cancer cells of MCF-7 line / N.V. Rusetskaya, N. Khariton, O.V. Yurchenko, V.F. Chekhun // Experimental Oncology. — 2011. — Т. 33, № 2. — С. 78-82. — Бібліогр.: 22 назв. — англ.
1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/138616 |
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| Language |
en
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| Relation |
Experimental Oncology
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| Publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
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