Quantitative analysis of SLC34A2 expression in different types of ovarian tumors
Vernadsky National Library of Ukraine
Переглянути архів Інформація| Поле | Співвідношення | |
| Title |
Quantitative analysis of SLC34A2 expression in different types of ovarian tumors
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| Creator |
Shyian, M.
Gryshkova, V. Kostianets, O. Gorshkov, V. Goloev, Yu. Goncharuk, I. Nespryadko, S. Vorobjova, L. Filonenko, V. Kiyamova, R. |
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Original contributions
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| Description |
Aim: The main purpose of this study was to estimate the SLC34A2 gene expression in normal ovary and different types of ovarian tumors. Methods: We have investigated SLC34A2 gene expression level in papillary serous, endometrioid, unspecified adenocarcinomas, benign tumors, and normal ovarian tissues using real-time PCR analysis. Differences in gene expression were calculated as fold changes in gene expression in ovarian carcinomas and benign tumors compared to normal ovary. Results: We have found that SLC34A2 gene was highly expressed in well-differentiated endometrioid and papillary serous ovarian carcinomas compared to low-differentiated endometrioid carcinomas, benign serous cystoadenomas and normal ovary. Analysis of SLC34A2 gene expression according to tumor differentiation level (poor- and well-differentiated) showed that SLC34A2 is up-regulated in well differentiated tumors. Conclusion: Upregulation of SLC34A2 gene expression in well-differentiated tumors may reflect cell differentiation processes during ovarian cancerogenesis and could serve as potential marker for ovarian cancer diagnosis and prognosis.
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| Date |
2018-06-19T10:45:54Z
2018-06-19T10:45:54Z 2011 |
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| Type |
Article
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| Identifier |
Quantitative analysis of SLC34A2 expression in different types of ovarian tumors / M. Shyian, V. Gryshkova, O. Kostianets, V. Gorshkov, Yu. Goloev, I. Goncharuk, S. Nespryadko, L. Vorobjova, V. Filonenko, R. Kiyamova // Experimental Oncology. — 2011. — Т. 33, № 2. — С. 94-98. — Бібліогр.: 32 назв. — англ.
1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/138632 |
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en
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| Relation |
Experimental Oncology
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| Publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
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