Pristine C60 fullereneS inhibit the rate of tumor growth and metastasis
Vernadsky National Library of Ukraine
Переглянути архів Інформація| Поле | Співвідношення | |
| Title |
Pristine C60 fullereneS inhibit the rate of tumor growth and metastasis
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| Creator |
Prylutska, S.V.
Burlaka, A.P. Prylutskyy, Yu.I. Ritter, U. Scharff, P. |
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| Subject |
Short communications
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| Description |
Aim: To estimate the impact of C60 fullerene aqueous solution (C60FAS) on the rate of transplanted malignant tumor growth and metastasis. Methods: Lewis lung carcinoma was transplanted into С57Bl/6J male mice. Conventional methods for the evaluation of antitumor and antimetastatic effects have been used. Results: The C60FAS at low single therapeutic dose of 5 mg/kg inhibited the growth of transplanted malignant tumor (antitumor effect) and metastasis (antimetastatic effect): the maximum therapeutic effect was found to be of 76.5% for the tumor growth inhibition; the increase of animal life span by 22% was found; the metastasis inhibition index was estimated as 48%. Conclusion: It was found that water-soluble pristine С60 fullerenes efficiently inhibit the transplanted malignant tumor growth and metastasis.
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| Date |
2018-06-19T10:47:06Z
2018-06-19T10:47:06Z 2011 |
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| Type |
Article
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| Identifier |
Pristine C60 fullereneS inhibit the rate of tumor growth and metastasis / S.V. Prylutska, A.P. Burlaka, Yu.I. Prylutskyy, U. Ritter, P. Scharff // Experimental Oncology. — 2011. — Т. 33, № 3. — С. 162-164. — Бібліогр.: 22 назв. — англ.
1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/138636 |
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| Language |
en
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| Relation |
Experimental Oncology
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| Publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
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