Запис Детальніше

Comparative study of dye-loaded liposome accumulation in sensitive and resistant human breast cancer cells

Vernadsky National Library of Ukraine

Переглянути архів Інформація
 
 
Поле Співвідношення
 
Title Comparative study of dye-loaded liposome accumulation in sensitive and resistant human breast cancer cells
 
Creator Yefimova, S.L.
Kurilchenko, I.Yu.
Tkacheva, T.N.
Rozhkov, V.A.
Sorokin, A.V.
Lukianova, N.Yu.
Bezdenezhnykh, N.A.
Malyukin, Yu.V.
Chekhun, V.F.
 
Subject Original contributions
 
Description The aim of this research is to study the dynamics and efficiency of liposome accumulation in sensitive and resistant human breast cancer cells. Methods: Methods of fluorescence microscopy, fluorescence microspectroscopy and MTT-test have been used. Results: The liposome-to-cell interaction and dye cellular uptake in sensitive, cisplatin-resistant and doxorubicin-resistant MCF-7 human breast cancer cells have been analyzed using time changes in both fluorescence resonance energy transfer signal from the donor probe DiO to the acceptor one DiI preloaded in liposomes and cell image brightness. Conclusion: Obtained results show that resistant cells accumulate dye-loaded liposomes more effectively and reveal more effective dye molecule cellular uptake.
 
Date 2018-06-19T11:43:19Z
2018-06-19T11:43:19Z
2012
 
Type Article
 
Identifier Comparative study of dye-loaded liposome accumulation in sensitive and resistant human breast cancer cells / S.L. Yefimova, I.Yu. Kurilchenko, T.N. Tkacheva, V.A. Rozhkov, A.V. Sorokin, N.Yu. Lukianova, N.A. Bezdenezhnykh, Yu.V. Malyukin, V.F. Chekhun // Experimental Oncology. — 2012. — Т. 34, № 2. — С. 101-106. — Бібліогр.: 14 назв. — англ.
1812-9269
http://dspace.nbuv.gov.ua/handle/123456789/138691
 
Language en
 
Relation Experimental Oncology
 
Publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України