Clearing the final hurdles to mitochondrial apoptosis: regulation post cytochrome C release
Vernadsky National Library of Ukraine
Переглянути архів Інформація| Поле | Співвідношення | |
| Title |
Clearing the final hurdles to mitochondrial apoptosis: regulation post cytochrome C release
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| Creator |
Monian, P.
Jiang, X. |
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| Subject |
Reviews
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| Description |
In mammalian cells, the mitochondrial pathway of apoptosis plays a key role in various biological processes and has been extensively studied. One of the signature features of this pathway is permeabilization of the outer mitochondrial membrane (MOMP) and thus release of cytochrome c into the cytoplasm to trigger subsequent activation of executioner caspases. Because MOMP is associated with loss of mitochondrial function, it has long been believed to represent an irreversible commitment to cell death. However, emerging data over the last decade has indicated that induction of MOMP alone is not always sufficient to fully commit cells to death. As such, it becomes important to understand how apoptosis is regulated post-MOMP. Here we recount evidence investigating if and how cells can survive MOMP, and why this might have important physiological consequences. Furthermore, we review recent progress made in understanding how the pathway is regulated beyond MOMP and cytochrome c release. This article is part of a Special Issue entitled “Apoptosis: Four Decades Later”.
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| Date |
2018-06-19T12:18:45Z
2018-06-19T12:18:45Z 2012 |
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| Type |
Article
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| Identifier |
Clearing the final hurdles to mitochondrial apoptosis: regulation post cytochrome C release / P. Monian, X. Jiang // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 185-191. — Бібліогр.: 117 назв. — англ.
1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/138731 |
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| Language |
en
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| Relation |
Experimental Oncology
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| Publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
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