Accelerated cellular senescence in solid tumor therapy
Vernadsky National Library of Ukraine
Переглянути архів Інформація| Поле | Співвідношення | |
| Title |
Accelerated cellular senescence in solid tumor therapy
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| Creator |
Wu, P.C.
Wang, Q. Grobman, L. Chu, E. Wu, D.Y. |
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| Subject |
Reviews
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| Description |
Accelerated cellular senescence (ACS) is an emerging concept that implicates sustained, telomere-independent cell cycle arrest of neoplastic cells in response to chemotherapeutic agents, ionizing radiation, oxidative stress, or the presence of selective oncogenic stimuli. Recent evidence suggests that a subset of tumor cells induced in a state of reversible ACS can escape cell cycle arrest and resume proliferation accounting for cancer progression. The purpose of this review is to describe our current understanding of ACS including signaling pathways of senescence escape, role of senescence biomarkers, and rationale for senescence-based therapy. This article is part of a Special Issue entitled “Apoptosis: Four Decades Later”.
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| Date |
2018-06-19T18:53:53Z
2018-06-19T18:53:53Z 2012 |
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| Type |
Article
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| Identifier |
Accelerated cellular senescence in solid tumor therapy / P.C. Wu, Q. Wang, L. Grobman, E. Chu, D.Y. Wu // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 298-305. — Бібліогр.: 85 назв. — англ.
1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/139056 |
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| Language |
en
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| Relation |
Experimental Oncology
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| Publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
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