Activity of thymidilate «salvage pathway» enzymes in human gastric cancer and blood serum: correlation with treatment modalities
Vernadsky National Library of Ukraine
Переглянути архів Інформація| Поле | Співвідношення | |
| Title |
Activity of thymidilate «salvage pathway» enzymes in human gastric cancer and blood serum: correlation with treatment modalities
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| Creator |
Borzenko, B.G.
Bakurova, E.M. Popovich, Yu.A. Sidyuk, E.A. Popovich, A.Y. |
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Original contributions
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| Description |
A comparative study of enzyme activity features of thymidilate “salvage pathway” synthesis in blood serum and tissues of different age patients with gastric cancer (T3–4N0-xM0) was carried out. Aim: To evaluate the diagnostic relevance of thymidilate metabolism enzymes activities and their association with tumor growth. Methods: Enzymes activities were determined by the radioisotope method and spectrophotometrically in tumor tissues and blood serum of 74 patients. Results: It was demonstrated that thymidine phosphorylase activity in gastric tumors is lower by 2.6 times as compared to non-neoplastic mucosa of resection margin. This being accompanied by decrease of its activity in the blood serum (from 47.9 ± 2.6 to 14.65 ± 2.4 nmol/min·mg, p < 0.001). An increase of thymidine kinase activity was revealed both in tumor tissues (more than 3.5 times) and in blood serum (from 3.9 ± 0,7 nmol/mg·h, to 6.8 ± 1.0 nmol/mg·h, p < 0.01). Changes in their activity in the postoperative period depended on the type of surgical procedure and tumor eradication. Conclusion: It could be suggested that control of individual dynamics of the enzymes activities in blood serum may be used as informative tool for monitoring of patients and treatment optimization.
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| Date |
2018-06-19T19:18:00Z
2018-06-19T19:18:00Z 2013 |
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| Type |
Article
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| Identifier |
Activity of thymidilate «salvage pathway» enzymes in human gastric cancer and blood serum: correlation with treatment modalities / B.G. Borzenko, E.M. Bakurova, Yu.A. Popovich, E.A. Sidyuk, A.Y. Popovich // Experimental Oncology. — 2013. — Т. 35, № 1. — С. 37-40. — Бібліогр.: 12 назв. — англ.
1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/139124 |
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| Language |
en
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| Relation |
Experimental Oncology
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| Publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
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