Запис Детальніше

Cytogenetic effects of neutron therapy in patients with parotid gland tumors and relapse of breast cancer

Vernadsky National Library of Ukraine

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Поле Співвідношення
 
Title Cytogenetic effects of neutron therapy in patients with parotid gland tumors and relapse of breast cancer
 
Creator Melnikov, A.A.
Vasilyev, S.A.
Musabaeva, L.I.
Velikaya, V.V.
Gribova, O.V.
Startseva, Zh.A.
Urazova, L.N.
Lebedev, I.N.
Choynzonov, E.L.
 
Subject Original contributions
 
Description Aim:To assess the frequency and spectrum of chromosome aberrations and micronuclei in peripheral blood lymphocytes of patients with parotid salivary gland tumors and relapse of breast cancer during the course of neutron therapy. Materials and Methods: Samples of peripheral blood were obtained from 9 patients with parotid salivary gland tumors (T3N0–3M0) and 8 patients with relapse of breast cancer before, after first fraction and at the end of neutron therapy. The treatment course specified 5.5–8.4 Gy (equivalent to 23–44 Gy of photon irradiation) with 1.3–2.2 Gy per fraction for patients with parotid salivary gland tumors and 4,8–8.0 Gy (equivalent to 30–40 Gy of photon irradiation) with 1.6 Gy per fraction for patients with relapse of breast cancer. Control group established for conventional cytogenetic analysis consisted of 15 healthy persons. Assessment of chromosome aberrations frequency was performed on routinely stained metaphase plates. Lymphocytes from the same patients were analyzed by micronucleus test in combination with fluorescent in situ hybridization (FISH) using pancentromeric DNA probe. Results: Level of chromosome aberrations and micronuclei significantly increased in lymphocytes of patients from both groups during neutron therapy (P < 0.05). This increase was mainly due to chromosome-type aberrations and centromere-negative micronuclei. The prevalent types of aberrations are in agreement with theoretical mechanisms of neutron effects on cells. Conclusion: Cytogenetic effects of fast neutron therapy in lymphocytes of patients with parotid salivary gland tumors and relapse of breast cancer were observed. A positive dynamics of radiation-induced chromosomal damages formation during the course was denoted in lymphocytes of cancer patients in both groups.
 
Date 2018-06-21T12:59:35Z
2018-06-21T12:59:35Z
2012
 
Type Article
 
Identifier Cytogenetic effects of neutron therapy in patients with parotid gland tumors and relapse of breast cancer / A.A. Melnikov, S.A. Vasilyev, L.I. Musabaeva, V.V. Velikaya, O.V. Gribova, Zh.A. Startseva, L.N. Urazova, I.N. Lebedev, E.L. Choynzonov // Experimental Oncology. — 2012. — Т. 34, № 4. — С. 354-357. — Бібліогр.: 19 назв. — англ.
1812-9269
http://dspace.nbuv.gov.ua/handle/123456789/139878
 
Language en
 
Relation Experimental Oncology
 
Publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України