Pathogenetic connection of lipid profile changes with left ventricle hypertrophic models depending on genes polymorphism' ace (I/D), eNOS (T894G) in patients with essential hypertension
Цифровий Репозиторій - Інтелектуальні Фонди Буковинського державного медичного університету
Переглянути архів Інформація| Поле | Співвідношення | |
| Title |
Pathogenetic connection of lipid profile changes with left ventricle hypertrophic models depending on genes polymorphism' ace (I/D), eNOS (T894G) in patients with essential hypertension
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| Creator |
Kushnir, O.V.
Sydorchuk, L.P. Iftoda, O.M. Sydorchuk, A.R. |
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| Subject |
arterial hypertension
genetic polymorphism lipid profile left ventricle hypertrophy артеріальна гіпертензія генетичний поліморфізм ліпідний профіль гіпертрофія лівого шлуночка артериальная гипертензия генетический полиморфизм липидный профиль гипертрофия левого желудочка |
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| Description |
Purpose. To establish the dependence of lipid profile changes in patients with essential arterial hypertension (EAH) on the type of left ventricular hypertrophy (LVH) and gene polymorphism of angiotensin-converting enzyme (ACE, I/D) and endothelial nitric oxide synthase (eNOS, T894G). Design/approach. In a prospective study 120 patients with EAH I-III severity stages: 12,5% (15) persons with EAH I, 60,0% (72) with EAH II, 27,5% (33) with EAH III; 48,3% (58) women and 51,7% (62) men, mean age 52,91±9,24, the disease duration from 2 to 28 years; the control group - 20 healthy individuals were involved. Ventricular mass (LVM) was evaluated by Echo-KG. Plasma lipids were studied by spectrophotometer, analyzed according to the recommendations of the ESC, ESH (2009). Genes' allele polymorphic areas of ACE (I/D), eNOS (T894G) were set by PCR analysis. Findings. High-risk groups of lipid profile changes in patients with EAH is a carriers of DD-genotype of ACE gene by increasing of low density cholesterol level and atherogenic index by 1,3 times (p<0,05). Genetic risk of dyslipidemia in EAH patients with unfavorable eccentric and concentric LVH and ACE and eNOS genes mutations (ID/TT, ID/ TG, DD/TG haplotypes) increases by 2,57-3,86 time (OR=2,57-3,86). Combination of Wild I-allele of ACE gene and G-allele of eNOS gene (II/GG, II/TG haplotypes) is protective against development of hypercholesterolemia in patients with unfavorable patterns of LVH (OR=0,12-0,94) and makes the chances of dyslipidemia risk the lowest in the population of EAH patients (p=0,05). Research limitations/implications. The study is limited by the peculiarities of laboratory and diagnostic tests. Originality/value. The original research without a prototype provides pathogenetic data for early detection and prevention of metabolic disorders in the presence/absence of LVH in patients with EAH. |
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| Date |
2018-06-25T07:05:02Z
2018-06-25T07:05:02Z 2015 |
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| Type |
Article
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| Identifier |
UDC 616.12-008.331.1:616.34-008.87
http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/13926 |
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| Language |
en
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| Format |
application/pdf
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| Publisher |
Клінічна та експериментальна патологія
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