TNFα receptor1 drives hypoxia-promoted invasiveness of human melanoma cells
Vernadsky National Library of Ukraine
Переглянути архів Інформація| Поле | Співвідношення | |
| Title |
TNFα receptor1 drives hypoxia-promoted invasiveness of human melanoma cells
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| Creator |
Marconi C.
Peppicelli S. Bianchini F. Calorini L. |
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Original contributions
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| Description |
Aim: Oxygen deprivation leading to hypoxia represents a common feature of advanced solid tumors, able to control several aspects of tumor progression. Indeed, ability to respond to changes in oxygen partial pressure represents a hallmark of malignant cells. Aim of this study is to disclose new pathway of hypoxia-induced tumor cell invasion. Materials and Methods: Hs294T human melanoma cells were grown in a gas mixture containing 0.3 % , and used to evaluate invasion on Matrigel-coated polycarbonate filters mounted in Boyden's chambers, MMP release and expression of inflammatory receptors and their ligands. Results: We demonstrate that hypoxia promotes the expression of TNFa receptor 1 (TNFαR1) able to drive a higher ability to penetrate Matrigel-coated filters of Hs294T human melanoma cells, an effect does not mediated by hypoxia-inducible factor (HIF)-1α. Conclusion: Expression inflammatory cytokine receptors in hypoxic human melanoma cells might provide a new target for improving strategies against local and distant tumor cell diffusion. Key Words: TNFa receptor 1, Hs294T human melanoma cells, hypoxia, cell invasiveness, metalloproteinase 2 and 9.
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| Date |
2019-01-19T16:38:55Z
2019-01-19T16:38:55Z 2013 |
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| Type |
Article
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| Identifier |
TNFα receptor1 drives hypoxia-promoted invasiveness of human melanoma cells / C. Marconi, S. Peppicelli, F. Bianchini, L. Calorini // Experimental Oncology. — 2013. — Т. 35, № 3. — С. 187-191. — Бібліогр.: 24 назв. — англ.
1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/145228 |
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| Language |
en
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| Relation |
Experimental Oncology
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| Publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
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