Antibodies against benzo
Vernadsky National Library of Ukraine
Переглянути архів Інформація| Поле | Співвідношення | |
| Title |
Antibodies against benzo
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| Creator |
Ustinov, V.A.
Matveeva, V.A. Kostyanko, M.A. Glushkov, A.N. |
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| Subject |
Original contributions
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| Description |
Aim: To evaluate the production of antibodies against benzo[a]pyrene (BF) (Ab1) and corresponding antiidiotypic antibodies (AM) in mice after immunization with BP-protein conjugate and in lung cancer patients. Materials and Methods: The Ab1 and AM levels were measured by non-competitive ELISA in blood serum of 10 mice immunized with BP-protein conjugate, and in blood serum of 288 healthy persons and 165 lung cancer patients. Results: The Ab] level of was 2-fold higher than Ab2 level in blood serum of BP-immunized mice. In lung cancer patients the Ab1 level was almost 3 times higher and the Ab2 level was by 30% higher than these indexes in healthy individuals. The Ab1/Ab2 ratio was 2 in BP-immunized mice and healthy individuals and l in lung cancer patients. Conclusion: Our data have shown that the Ab1/Ab2 ratio in lung cancer patients differ from that in healthy individuals and is close to the Ab1/Ab2 ratio in BP-immunized mouse. Key Words: benzo[a]pyrene, antibodies, lung cancer.
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| Date |
2019-01-19T20:48:59Z
2019-01-19T20:48:59Z 2013 |
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| Type |
Article
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| Identifier |
Antibodies against benzo / V.A. Ustinov, V.A. Matveeva, M.A. Kostyanko, A.N. Glushkov // Experimental Oncology. — 2013. — Т. 35, № 3. — С. 207-210. — Бібліогр.: 16 назв. — англ.
1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/145239 |
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| Language |
en
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| Relation |
Experimental Oncology
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| Publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
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