Overproduction of free radical species in embryonal cells exposed to low intensity radiofrequency radiation
Vernadsky National Library of Ukraine
Переглянути архів Інформація| Поле | Співвідношення | |
| Title |
Overproduction of free radical species in embryonal cells exposed to low intensity radiofrequency radiation
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| Creator |
Burlaka, A.
Tsybulin, O. Sidorik, E. Lukin, S. Polishuk, V. Tsehmistrenko, S. Yakymenko, I. |
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| Subject |
Original contributions
Original contributions |
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| Description |
Aim: Long-term exposure of humans to low intensity radiofrequency electromagnetic radiation (RF-EMR) leads to a statistically significant increase in tumor incidence. Mechanisms of such the effects are unclear, but features of oxidative stress in living cells under RF-EMR exposure were previously reported. Our study aims to assess a production of initial free radical species, which lead to oxidative stress in the cell. Materials and Methods: Embryos of Japanese quails were exposed in ovo to extremely low intensity RF-EMR of GSM 900 MHz (0.25 µW/cm2 ) during 158–360 h discontinuously (48 c — ON, 12 c — OFF) before and in the initial stages of development. The levels of superoxide (O2· - ), nitrogen oxide (NO·), thiobarbituric acid reactive substances (TBARS), 8-oxo-2’-deoxyguanosine (8-oxo-dG) and antioxidant enzymes’ activities were assessed in cells/tissues of 38-h, 5- and 10-day RF-EMR exposed and unexposed embryos. Results: The exposure resulted in a significant persistent overproduction of superoxide and nitrogen oxide in embryo cells during all period of analyses. As a result, significantly increased levels of TBARS and 8-oxodG followed by significantly decreased levels of superoxide dismutase and catalase activities were developed in the exposed embryo cells. Conclusion: Exposure of developing quail embryos to extremely low intensity RF-EMR of GSM 900 MHz during at least one hundred and fifty-eight hours leads to a significant overproduction of free radicals/reactive oxygen species and oxidative damage of DNA in embryo cells. These oxidative changes may lead to pathologies up to oncogenic transformation of cells |
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| Date |
2019-01-19T20:56:23Z
2019-01-19T20:56:23Z 2013 |
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| Type |
Article
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| Identifier |
Overproduction of free radical species in embryonal cells exposed to low intensity radiofrequency radiation / A. Burlaka, O. Tsybulin, E. Sidorik, S. Lukin, V. Polishuk, S. Tsehmistrenko, I. Yakymenko // Experimental Oncology. — 2013. — Т. 35, № 3. — С. 219-225. — Бібліогр.: 60 назв. — англ.
1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/145241 |
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| Language |
en
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| Relation |
Experimental Oncology
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| Publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
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