Markers of epithelial-mesenchymal transition in renal cell carcinoma
Vernadsky National Library of Ukraine
Переглянути архів Інформація| Поле | Співвідношення | |
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Markers of epithelial-mesenchymal transition in renal cell carcinoma
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| Creator |
Dumanskiy, Y.V.
Kudriashov, A.G. Vasilenko, I.V. Kondratyuk, R.B. Gulkov, Y.K. Сhystiakov, R.S. |
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Arrticles not related to special issue topics
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| Description |
Aim - to study the influence of markers of epithelial-mesenchymal transition (EMT) on a renal cell carcinoma (RCC) prognosis. The surgical material of 47 RCC patients who underwent nephrectomy was studied. RCC patients were distributed in two groups: a short-term survival group (3 - 6 months) and a long-term survival group (17 - 24 months). EMT markers expression was assessed by immunohistochemical methods. It was determined that the rate of spindle-cell EMT was 96,4 % in a short-term survival group and 42,1 % in a long-term survival group. High rate Furhman's nuclear atypia, i.e. degree 3 - 4 occurred in 100 % of cases in a short-term survival group versus 68,4 % in a longterm survival group. Conclusion: the rate of spindle-cell EMT in RCC may serve a more sensible prognostic factor than the degree of Furhman's nuclear atypia. Key Words: renal cell carcinoma, epithelial-mesenchymal transition, the degree of Furhman’s nuclear atypia.
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| Date |
2019-01-20T09:05:57Z
2019-01-20T09:05:57Z 2013 |
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| Type |
Article
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| Identifier |
Markers of epithelial-mesenchymal transition in renal cell carcinoma / Y.V. Dumanskiy, A.G. Kudriashov, I.V. Vasilenko, R.B. Kondratyuk, Y.K. Gulkov, R.S. Сhystiakov // Experimental Oncology. — 2013. — Т. 35, № 4. — С. 325-327. — Бібліогр.: 14 назв. — англ.
1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/145287 |
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| Language |
en
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| Relation |
Experimental Oncology
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| Publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
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