Preclinical antitumor activity of the diindolylmethane formulation in xenograft mouse model of prostate cancer
Vernadsky National Library of Ukraine
Переглянути архів Інформація| Поле | Співвідношення | |
| Title |
Preclinical antitumor activity of the diindolylmethane formulation in xenograft mouse model of prostate cancer
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| Creator |
Kiselev, V.I.
Drukh, V.M. Muyzhnek, E.L. Kuznetsov, I.N. Pchelintseva, O.I. Paltsev, M.A. |
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Original contributions
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| Description |
Aim: Preclinical study of the specific anticancer pharmacological activity of the formulation containing active substance 3,3ʹ-diindolylmethane (DIM), cod liver oil, polysorbate 80 and α-tocopherol acetate (vitamin E), in vivo in a xenograft animal model of LNCaP. Materials and Methods: The DIM, cod liver oil, polysorbate 80 and α-tocopherol acetate (vitamin E) formulation was intragastrically administered to BALB/c-nude (nu/nu) mice during 33 days post inoculation at the dose of 133 mg/kg/day. Antitumor activity of the test drug was estimated by the rate of tumor growth inhibition (T/C% — treated versus control), dividing the tumor volumes from treatment groups with the control groups. Results: Statistically significant tumor xenograft regressions have been shown in group which received the DIM, cod liver oil, polysorbate 80 and α-tocopherol acetate (vitamin E) on the 37th day of observation post inoculation. The highest antitumor activity was achieved on the 39th day (T/C = 16,8%). Therapeutic effect lasts for 6 days after the end of therapy period. Conclusion: Our findings demonstrate inhibitory effect of the formulation on tumor development in the xenograft animal model due to the tumor growth rate reduction. Key Words: 3,3´-diindolylmethane, bioavailability, anticancer activity, xenograft model, LNCaP cell line, preclinical studies.
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| Date |
2019-01-20T16:36:21Z
2019-01-20T16:36:21Z 2014 |
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| Type |
Article
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| Identifier |
Preclinical antitumor activity of the diindolylmethane formulation in xenograft mouse model of prostate cancer / V.I. Kiselev, V.M. Drukh, E.L. Muyzhnek, I.N. Kuznetsov, O.I. Pchelintseva, M.A. Paltsev // Experimental Oncology. — 2014. — Т. 36, № 2. — С. 90-93. — Бібліогр.: 20 назв. — англ.
1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/145337 |
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| Language |
en
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| Relation |
Experimental Oncology
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| Publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
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