The immunophenotype of adult t acute lymphoblastic leukemia in Morocco
Vernadsky National Library of Ukraine
Переглянути архів Інформація| Поле | Співвідношення | |
| Title |
The immunophenotype of adult t acute lymphoblastic leukemia in Morocco
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| Creator |
Lahjouji, A.
Bachir, F. Bennani, S. Quessar, A. Amzazi, S. |
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| Subject |
Original contributions
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| Description |
Background: There is paucity of detailed studies of adult T cell acute lymphoblastic leukemia (T-ALL) in developing countries reflecting the condition of these patients including clinical and biological features. Objective: This study was carried out to analyze the immunophenotypic characteristics of 40 Moroccan patients with T-ALL and its association with biological and clinical features. Patients and Methods: Between 2006 and 2009, 130 adult patients diagnosed with acute lymphoblastic leukemia (ALL) were immunophenotyped by 3-color flow cytometry using a panel of monoclonal antibodies. Cases presenting features of a T-lineage phenotype were subjected to detailed analysis including immunophenotypic, clinical and biological parameters. Results: Proportion of T-ALL among ALL Moroccan patients was 31.0%. Median age of patients was 28 years. Twenty-nine patients were females and 11 were males. 45.0% of patients (18/40) had features of immature T-ALL stages (pro-T and pre-T ALL), 30.0% (12/40) of CD1a+ cortical T-ALL stage and 25.0% (10/40) had a characteristic phenotype of medullary T-ALL. The frequencies of progenitor cell markers CD10, CD34 and TdT expression were 14.0; 57.5% and 50.0% respectively. The aberrant expression of B lineage associated antigen CD79a were positive in 20.5% of the cases and the aberrant expression of myeloid antigens CD13 and/or CD33 was found in 22 (55.0%) cases. No significant association was encountered between TdT, CD34 or myeloid antigens positivity and high risk features at presentation as age, sex, and white blood cells. However, myeloid antigens (CD13 and/or CD33) was significantly associated with T-cell maturation stages (p = 0.009). Conclusion: To the best of our knowledge, this is the first report from North Africa of immunophenotypic study on adult T-ALL. Our findings indicate that the proportion of T-ALL among ALL in Morocco is similar to that reported in others Mediterranean countries like France and Italy and that myeloid-associated antigens expression is frequently associated with immature immunophenotype. Key Words: adult T cell acute lymphoblastic leukemia, immunophenotypic analysis, immunological subtypes, myeloid and T-cell antigens.
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| Date |
2019-01-22T10:40:35Z
2019-01-22T10:40:35Z 2015 |
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| Type |
Article
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| Identifier |
The immunophenotype of adult t acute lymphoblastic leukemia in Morocco / A. Lahjouji, F. Bachir, S. Bennani, A. Quessar, S. Amzazi // Experimental Oncology. — 2015. — Т. 37, № 1. — С. 64-69. — Бібліогр.: 41 назв. — англ.
1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/145457 |
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| Language |
en
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| Relation |
Experimental Oncology
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| Publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
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