Сhanges of proteinuria and acid-regulating kidney function of mature rats with slow and rapid acetylation type under conditions of subacute cadmium-nitrate intoxication
Цифровий Репозиторій - Інтелектуальні Фонди Буковинського державного медичного університету
Переглянути архів Інформація| Поле | Співвідношення | |
| Title |
Сhanges of proteinuria and acid-regulating kidney function of mature rats with slow and rapid acetylation type under conditions of subacute cadmium-nitrate intoxication
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| Creator |
Kmet, T.I
Filipets, N.D Hrachova, T.I Bulyk, T. S. Kushnir, O.V. |
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| Subject |
cadmium-nitrate intoxication
mature rats slow and rapid acetylation type kidneys acid-regulating function proteinuria кадмиево-нитратная интоксикация половозрелые крысы медленный и быстрый тип ацетилирования почки кислоторегулирующая функция протеинурия |
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| Description |
The experiments conducted on non-linear mature laboratory albino rats determined that under conditions of subacute cadmium-nitrate intoxication the indices of proteinuria and acid-regulating renal function depend on acetylation phenotype. Unlike rapid acetylators considerable increase of protein concentration in urine (192,8 %, р<0,05) and standardized by glomerular filtration protein excretion (141,7 %, р<0,05) are indicative of higher susceptibility of rats with slow acetylation type to nephrotoxic action of cadmium chloride and sodium nitrate. Lack of protein loss with urine and adaptive-compensative character of acid-regulating renal function changes directed to elimination of hydrogen ions excess from the body give evidence concerning less intensive damage of the nephron tubular portion in rats with rapid acetylation type, and at the same time do not exclude development of nephropathy. In order to confirm the significance of acetylation phenotype for assessment of susceptibility and degree of cadmium-nitrate damage of the kidneys the condition of other renal functions should be examined with analysis of biochemical criteria of nephrotoxicity, which is of an important practical value for the selection of appropriate pharmacotherapy.
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| Date |
2019-01-25T10:01:55Z
2019-01-25T10:01:55Z 2018 |
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| Type |
Article
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| Identifier |
http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/14675
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| Language |
en
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| Format |
application/pdf
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| Publisher |
Georgian Medical News
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