Markers of the epithelial-mesenchymal transition in cells of endometrial carcinoma
Vernadsky National Library of Ukraine
Переглянути архів Інформація| Поле | Співвідношення | |
| Title |
Markers of the epithelial-mesenchymal transition in cells of endometrial carcinoma
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| Creator |
Nesina, I.P.
Iurchenko, N.P. Buchynska, L.G. |
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Original contributions
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| Description |
Aim: To study the expression of adhesion markers (E-cadherin, β-catenin and vimentin) associated with epithelial-mesenchymal transition (EMT) and their role in progression of endometrial carcinoma (EC). Materials and Methods: Expression of E-cadherin, β-catenin and vimentin was studied immunohistochemically in the samples of surgical material of 55 EC patients stage I–III. The proliferation index was determined by flow cytometry. Results: In the group of vimentin-negative EC, tumors of low differentiation grade and deep invasion in myometrium as well as high expression of E-cadherin and β-catenin prevailed compared with the cases with high expression of vimentin. In addition, in EC with high expression of vimentin, an increase in the number of cells with expression of E-cadherin in the cytoplasm (78.9 ± 3.6%) and β-catenin with cytoplasmic-nuclear localization (73.7 ± 3.2%) was observed compared with these indices in vimentin-negative tumors (45.4 ± 4.2%, p < 0.001 and 54.5 ± 2.6%, respectively, p < 0.005), which may indicate EMT-associated changes in EC with high expression of vimentin. Conclusions: The progression of the endometrioid carcinoma may occur in the setting of various molecular changes, in particular, with decreased expression of E-cadherin and β-catenin and high expression of vimentin, or in the absence of vimentin, utilizing other mechanisms of regulation of proliferative and metastatic potential. Key Words: endometrial cancer, proliferation index, E-cadherin, β-catenin, vimentin.
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| Date |
2019-01-25T16:00:10Z
2019-01-25T16:00:10Z 2018 |
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| Type |
Article
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| Identifier |
Markers of the epithelial-mesenchymal transition in cells of endometrial carcinoma / I.P. Nesina, N.P. Iurchenko, L.G. Buchynska // Experimental Oncology. — 2018 — Т. 40, № 3. — С. 218–222. — Бібліогр.: 33 назв. — англ.
1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/145637 |
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| Language |
en
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| Relation |
Experimental Oncology
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| Publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
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