Interaction of new fluorescent ict-dyes with lipid membranes
eKhNUIR
Переглянути архів Інформація| Поле | Співвідношення | |
| Title |
Interaction of new fluorescent ict-dyes with lipid membranes
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| Creator |
Zhytnyakovskaya, O.A.
Kutsenko, O.K. Trusova, V.M. Gorbenko, G.P. Deligeorgiev, T. Kaloyanova, S. Lesev, N. |
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| Subject |
ICT dyes
liposomes phosphatidylcholine cardiolipin cholesterol |
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| Description |
The present study was undertaken to evaluate the sensitivity of newly synthesized ICT dyes to the changes in physicochemical properties of lipid bilayer. Partitioning of ICT4 into lipid phase of the model membranes composed of zwitterionic lipid phosphatidylcholine (PC) and its mixtures with anionic lipid cardiolipin and cholesterol was followed by the decrease of fluorescence quantum yield and short- wavelength shift of emission maximum. On the contrary, ICT2 exhibited tenfold increase of the quantum yield upon interaction with liposomes, without any shift of the emission maximum. Analysis of the partition coefficients showed that inclusion of cardiolipin and choleterol into phosphatidylcholine bilayer gives rise to increase of the ICT2 incorporation into lipid phase compared to the neat phosphatidylcholine membrane.
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| Date |
2012-12-04T00:15:45Z
2012-12-04T00:15:45Z 2010 |
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| Type |
Article
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| Identifier |
Журнал
http://dspace.univer.kharkov.ua/handle/123456789/7228 |
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| Language |
en
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| Relation |
Биофизический вестник;25(2)
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| Publisher |
Харьковский Национальный Университет им. В.Н.Каразина
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